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  1. 原著論文

Do TSH, FT3 and FT4 impact BAT visualization of clinical FDG-PET/CT images?

https://repo.qst.go.jp/records/49039
https://repo.qst.go.jp/records/49039
fda2e734-4431-4727-9579-8770594fc7c0
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-05-17
タイトル
タイトル Do TSH, FT3 and FT4 impact BAT visualization of clinical FDG-PET/CT images?
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Nishii, Ryuichi

× Nishii, Ryuichi

WEKO 494578

Nishii, Ryuichi

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Nagamachi, Shigeki

× Nagamachi, Shigeki

WEKO 494579

Nagamachi, Shigeki

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Mizutani, Yuichi

× Mizutani, Yuichi

WEKO 494580

Mizutani, Yuichi

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Terada, Tamasa

× Terada, Tamasa

WEKO 494581

Terada, Tamasa

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Kiyohara, Syogo

× Kiyohara, Syogo

WEKO 494582

Kiyohara, Syogo

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Wakamatsu, Hideyuki

× Wakamatsu, Hideyuki

WEKO 494583

Wakamatsu, Hideyuki

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Fujita, Seigo

× Fujita, Seigo

WEKO 494584

Fujita, Seigo

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Higashi, Tatsuya

× Higashi, Tatsuya

WEKO 494585

Higashi, Tatsuya

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Yoshinaga, Keiichiro

× Yoshinaga, Keiichiro

WEKO 494586

Yoshinaga, Keiichiro

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Saga, Tsuneo

× Saga, Tsuneo

WEKO 494587

Saga, Tsuneo

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西井 龍一

× 西井 龍一

WEKO 494588

en 西井 龍一

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東 達也

× 東 達也

WEKO 494589

en 東 達也

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吉永 恵一郎

× 吉永 恵一郎

WEKO 494590

en 吉永 恵一郎

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佐賀 恒夫

× 佐賀 恒夫

WEKO 494591

en 佐賀 恒夫

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抄録
内容記述タイプ Abstract
内容記述 [Objectives] Several researchers have reported that type 2 idothyronine deiodinase (D2) is considered to be important for the synergism of thyroid hormone (TH) and to be required to generate the T3 from T4 in the BAT, which maintains the normal acute thermogenic function of BAT. However, to date, details about the relationship between visualization of BAT on FDG-PET/CT and the effect of TH remain unknown. In this study, we retrospectively analyze BAT visualization on FDG-PET/CT in patients with various conditions and TH levels.
[Methods] In this retrospective investigation, we reviewed images from all patients who underwent clinical FDG-PET/CT studies from October 2010 to July 2015, and categorized patients in 5 groups: (i) Thyroid hormone withdrawal (THW) group; (ii) Recombinant human thyrotropin (rhTSH) group; (iii) Hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group. Total of sixty-two FDG-PET/CT imaging studies in fifty-nine patients were performed. A total of sixty-two FDG-PET/CT imaging studies in fifty-nine patients were performed. To compare each group; gender; age; body weight; serum TSH, FT3, FT4 levels; and outside temperature were evaluated.
[Results] No significant visualization of BAT was noted in any of the images in the THW, rhTSH, hypothyroidism, and hyperthyroidism groups. Serum TSH level was significantly high in the rhTSH group and significantly low in the hyperthyroidism group. Elevated serum TSH was noted in the THW and hypothyroidism group. All patients in the BAT group were in a euthyroid state. When the BAT-negative and -positive patient groups were compared, it was noted that the minimum and maximum temperature on the day of the PET study and maximum temperature of the one day before of the PET study were significantly lower in BAT positive group than in all others those of other groups.
[Conclusions] Elevated TSH condition before RIT, hyperthyroidism or
hypothyroidism did not significantly impact BAT visualization of clinical FDG-PET/CT images.
書誌情報 Contrast Media & Molecular Imaging

巻 2018, 号 8, p. 1-9, 発行日 2018-02
出版者
出版者 Hindawi (John Wiley & Sons, Inc.)
ISSN
収録物識別子タイプ ISSN
収録物識別子 1555-4309
PubMed番号
識別子タイプ PMID
関連識別子 29666563
DOI
識別子タイプ DOI
関連識別子 10.1155/2018/4898365
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