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Differences in responses to X-ray exposure between osteoclast and osteoblast cells
https://repo.qst.go.jp/records/49037
https://repo.qst.go.jp/records/49037343938fc-1cf1-41ea-9232-67e1fef50abb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-17 | |||||
| タイトル | ||||||
| タイトル | Differences in responses to X-ray exposure between osteoclast and osteoblast cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Jian
× Zhang, Jian× Ziyang, Wang× Wu, Anqing× Nie, Jing× Pei, Hailong× Hu, Wentao× Wang, Bing× Shang, Peng× Li, Bingyan× Zhou, Guangming× 張 健× うー 安きん× Ｐｅｉ Ｈａｉｌｏｎｇ× 胡 文涛× 王 冰× 李 冰燕× Ｚｈｏｕ Ｇｕａｎｇｍｉｎｇ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation-induced bone loss is a potential health concern for cancer patients undergoing radiotherapy. Enhanced bone resorption by osteoclasts and decreased bone formation by osteoblasts were thought to be the main reasons. In this study, we showed that both pre-differentiating and differentiating osteoclasts were relatively sensitive to X-rays compared with osteoblasts. X-rays decreased cell viability to a greater degree in RAW264.7 cells and in differentiating cells than than in osteoblastic MC3T3-E1 cells. X-rays at up to 8 Gy had little effects on osteoblast mineralization. In contrast, X-rays at 1 Gy induced enhanced osteoclastogenesis by enhanced cell fusion, but had no effects on bone resorption. A higher dose of X-rays at 8 Gy, however, had an inhibitory effect on bone resorption. In addition, actin ring formation was disrupted by 8 Gy of X-rays and reorganized into clusters. An increased activity of Caspase 3 was found after X-ray exposure. Actin disorganization and increased apoptosis may be the potential effects of X-rays at high doses, by inhibiting osteoclast differentiation. Taken together, our data indicate high radiosensitivity of osteoclasts. X-ray irradiation at relatively low doses can activate osteoclastogenesis, but not osteogenic differentiation. The radiosensitive osteoclasts are the potentially responsive cells for X-ray-induced bone loss. KEYWORDS: ionizing radiation, osteoblasts, osteoclasts, differentiation |
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| 書誌情報 |
Journal of Radiation Research 巻 58, 号 6, p. 791-802, 発行日 2017-04 |
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| 出版者 | ||||||
| 出版者 | オックスフォード大学出版局 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrx026 | |||||
