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High spatial resolution microdosimetry with monolithic ΔE-E detector on 12C beam: Monte Carlo simulations and experiment
https://repo.qst.go.jp/records/49021
https://repo.qst.go.jp/records/49021f9adf041-1dd6-4986-ba2a-07d644ade120
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-17 | |||||
| タイトル | ||||||
| タイトル | High spatial resolution microdosimetry with monolithic ΔE-E detector on 12C beam: Monte Carlo simulations and experiment | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ｔｒａｎ, Ｔｈｕｙ Ｌｉｎｈ
× Ｔｒａｎ, Ｔｈｕｙ Ｌｉｎｈ× ＢＯＬＳＴ, Ｄａｖｉｄ× SusannaGuatelli× Biasi, Giordano× Ｆａｚｚｉ, Ａｌｂｅｒｔｏ× Ｓａｇｉａ, Ｅｌｅｎｉ× Ｐｒｏｋｏｐｏｖｉｃｈ, Ａｎｔｈｏｎｙ× I.Reinhard, Mark× C., Keat Ying× Ｐｅｔａｓｅｃｃａ, Ｍａｒｃｏ× L., F. Lerch Michael× Pola, Andrea× Agosteo, Stefano× 松藤, 成弘× Jackson, Michael× Ａｎａｔｏｌｙ, Ｒｏｚｅｎｆｅｌｄ× Ｔｒａｎ Ｔｈｕｙ Ｌｉｎｈ× ＢＯＬＳＴ Ｄａｖｉｄ× Ｆａｚｚｉ Ａｌｂｅｒｔｏ× Ｓａｇｉａ Ｅｌｅｎｉ× Ｐｒｏｋｏｐｏｖｉｃｈ Ａｎｔｈｏｎｙ× Ｐｅｔａｓｅｃｃａ Ｍａｒｃｏ× 松藤 成弘× Ａｎａｔｏｌｙ Ｒｏｚｅｎｆｅｌｄ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nuclear fragmentation produced in 12C ion therapeutic beams contributes significantly to the Relative Biological Effectiveness (RBE)—weighted dose in the distal edge of the Spread out Bragg Peak (SOBP) and surrounding tissues in out-of-field. Complex mixed radiation field originated by the therapeutic 12C ion beam in a phantom is difficult to measure. This study presents a new method to characterise the radiation field produced in a 12C ion beam using a monolithic E-E telescope which provides the capability to identify the particle components of the mixed radiation field as well as the microdosimetric spectra that allows derivation of the RBE based on a radiobiological model. The response of the monolithic E-E telescope to a 290 MeV/u 12C ion beam at defined positions along the pristine Bragg Peak was studied using the Geant4 Monte Carlo toolkit. The microdosimetric spectra derived from the E stage and the two-dimensional scatter plots of energy deposition in E and E stages of the device in coincidence are presented, as calculated in-field and out-of-field. Partial dose weighted contribution to the microdosimetric spectra from nuclear fragments and recoils, such as 1H, 4He, 3He, 7Li, 9Be and 11B, have been analysed for each position. Comparison of simulation and experimental results are presented and demonstrates that the microdosimetric spectra changes dramatically within 0.5 mm depth increments close to and at the distal edge of the Bragg Peak which is impossible to identify using conventional Tissue Equivalent Proportional Counter (TEPC). | |||||
| 書誌情報 |
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 巻 887, p. 70-80, 発行日 2018-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nima.2017.12.079 | |||||
