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Radiation exposure enhances hepatocyte proliferation in neonatal mice but not in adult mice
https://repo.qst.go.jp/records/49001
https://repo.qst.go.jp/records/490011cdce21f-f361-4665-b794-dd090d9e6cf9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-15 | |||||
| タイトル | ||||||
| タイトル | Radiation exposure enhances hepatocyte proliferation in neonatal mice but not in adult mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Sawa, Yurika× Blyth, Benjamin× Tsuruoka, Chizuru× Nogawa, Hiroyuki× Shimada, Yoshiya× Kakinuma, Shizuko× 尚 奕× 澤 百合香× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 鶴岡 千鶴× 島田 義也× 柿沼 志津子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Intuitively, irradiation of an infant organ before it undergoes development-related expansion would be expected to confer greater cancer risk than irradiation of a fully-developed adult tissue, and this is generally observed. However, if tissues also vary in their initial responses to radiation depending on age, the interplay between tissue- and age-dependent risk would potentially be quite complex. We have previously shown opposing age-dependent induction of apoptosis for the intestinal epithelium and hematopoietic cells in mice, but such data are not yet available for the liver. Here, we have examined markers of DNA damage, initiation of DNA damage responses, cell cycle arrest, apoptosis and proliferation, as well as gene expression, in the B6C3F1 mouse liver over the hours and days following irradiation of mice at 1 or 7 weeks of age. We found that induction and resolution of radiation-induced DNA damage is not accompanied by significant changes in these cellular endpoints in the adult liver, while in infant hepatocytes modest induction of p53 accumulation and p21-mediated cell cycle arrest in a small fraction of damaged cells was overshadowed by a further stimulation of proliferation over the relatively high levels already found in the neonatal liver. We observed distinct expression of genes which regulate cell division between the ages which may contribute to the differential responses. These data suggest that the growth factor signaling environment of the infant liver may mediate radiation-induced proliferation and increased liver cancer risk following irradiation during early life. | |||||
| 書誌情報 |
Radiation Research 巻 188, 号 2, p. 235-241, 発行日 2017-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28581892 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RR14563.1 | |||||
