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Prognostic factors of adenoid cystic carcinoma of the head and neck in carbon-ion radiotherapy: The impact of histological subtypes
https://repo.qst.go.jp/records/48949
https://repo.qst.go.jp/records/489495b0da66d-01e6-442e-9355-d0b269cc04dd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-11 | |||||
| タイトル | ||||||
| タイトル | Prognostic factors of adenoid cystic carcinoma of the head and neck in carbon-ion radiotherapy: The impact of histological subtypes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikawa, Hiroaki
× Ikawa, Hiroaki× Koto, Masashi× Takagi, Ryo× Ebner, Daniel× Hasegawa, Azusa× Naganawa, Kensuke× Takenouchi, Toshinao× Nagao, Toshitaka× Nomura, Takeshi× Shibahara, Takahiko× Tsuji, Hiroshi× Kamada, Tadashi× 伊川 裕明× 小藤 昌志× 高木 亮× エブナー ダニエル× 長谷川 安都佐× 長縄 憲亮× 武内 利直× 長尾 俊孝× 柴原 孝彦× 辻 比呂志× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT). Material and methods: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57.6 or 64.0 Gy (RBE) was administered in 16 fractions. Histological grading was defined as the presence or absence of a solid growth pattern. Results: Median follow-up was 60 months. 5-Year local control (LC), overall survival (OS) and distant metastasis free survival (DMFS) of all patients were 68.6%, 74.8% and 65.7%, respectively. On multivariate analysis, the prescribed dose (p = 0.001) and gross tumor volume (p = 0.002) were significant independent risk factors for LC. No significant difference for local control of solid/non-solid growth patterns was found (p = 0.093). Solid growth pattern was an independent risk factor for both OS (p = 0.033) and DMFS (p = 0.024). Conclusions: CIRT appears able to locally control solid growth pattern ACC in the head and neck. Improved intervention is needed to extend DMFS and OS. |
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| 書誌情報 |
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 巻 123, 号 3, p. 387-393, 発行日 2017-05 |
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| 出版者 | ||||||
| 出版者 | Elsevier Scientific Publishers | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28528680 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radonc.2017.04.026 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S0167814017303705 | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S0167814017303705 | |||||
