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First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303
https://repo.qst.go.jp/records/48941
https://repo.qst.go.jp/records/48941a809a3c0-8c46-4679-b247-354d9f6b3585
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-10 | |||||
| タイトル | ||||||
| タイトル | First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamasaki, Tomoteru
× Yamasaki, Tomoteru× Mori, Wakana× Zhang, Yiding× Hatori, Akiko× Fujinaga, Masayuki× Wakizaka, Hidekatsu× Kurihara, Yusuke× Lu, Wang× Nengaki, Nobuki× Ohya, Tomoyuki× Liang, Huan× Ming-Rong, Zhang× Yamasaki, Tomoteru× Mori, Wakana× Zhang, Yiding× Hatori, Akiko× Fujinaga, Masayuki× Wakizaka, Hidekatsu× Kurihara, Yusuke× Lu, Wang× Nengaki, Nobuki× Ohya, Tomoyuki× Liang, Huan× Ming-Rong, Zhang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Monoacylglycerol lipase (MAGL) is a main regulator of the endocannabinoid system within the central nervous system (CNS). Recently, [11C]SAR127303 was developed as a promising radioligand for MAGL imaging. In this study, we aimed to quantify regional MAGL concentrations in the rat brain using positron emission tomography (PET) with [11C]SAR127303. An irreversible two-tissue compartment model (2-TCMi, k4 = 0) analysis was conducted to estimate quantitative parameters (k3, Ki2-TCMi, and λk3). These parameters were successfully obtained with high identifiability (<10 %COV) for the following regions ranked in order from highest to lowest: cingulate cortex > striatum > hippocampus > thalamus > cerebellum > hypothalamus ≈ pons. In vitro autoradiographs using [11C]SAR127303 showed a heterogeneous distribution of radioactivity, as seen in the PET images. The Ki2-TCMi and λk3 values correlated relatively highly with in vitro binding (r > 0.4, P < 0.005). The Ki2-TCMi values showed high correlation and low underestimation (<10%) compared with the slope of a Patlak plot analysis with linear regression (KiPatlak). In conclusion, we successfully estimated regional net uptake value of [11C]SAR127303 reflecting MAGL concentrations in rat brain regions for the first time. | |||||
| 書誌情報 |
NeuroImage 巻 176, p. 313-320, 発行日 2018-05 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-8119 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neuroimage.2018.05.015 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1053811918304130?via%3Dihub | |||||
