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Photodynamic therapy for biliary tract organ via a novel ultra-small composite optical fiberscope
https://repo.qst.go.jp/records/48922
https://repo.qst.go.jp/records/48922609eeeab-2d7b-47dc-9774-08a3fc3c1c01
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-08 | |||||
| タイトル | ||||||
| タイトル | Photodynamic therapy for biliary tract organ via a novel ultra-small composite optical fiberscope | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kasuya, Kazuhiko
× Kasuya, Kazuhiko× 岡, 潔× Soya, Ryoko× Tsuchiya, Takaaki× Itoi, Takao× Tsuchida, Akihiko× 岡 潔 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Photodynamic therapy (PDT) is a method to treat tumors utilizing photodynamic reactions between photosensitive substances with tumor affinity and lasers. For overall bile duct cancers, PDT shows an effect to resolve stenosis by cancer and improves the prognosis, but when it is limited to intrahepatic bile duct cancers, some modification of laser irradiation is necessary because surrounding hepatocytes incorporate a large amount of photosensitive substances. Moreover, the intrahepatic bile duct is thin and a guide sheath and thin fiber are necessary to transport a probe for laser irradiation to the target region. To target a thin intrahepatic bile duct, we developed a parallel-type ultra-small composite optical fiberscope (COF) with an outer diameter of 1 mm or smaller, and performed PDT in an animal model using talaporfin sodium (product name: Laserphyrin), which cells (hepatocytes) rapidly excrete and is applicable with a long-wavelength laser having high tissue penetrating ability. We confirmed that Laserphyrin does not cause necrotic changes in the normal biliary tract mucosa. In addition, COF images with a certain quality could be acquired. | |||||
| 書誌情報 |
EXPERIMENTAL AND THERAPEUTIC MEDICINE 巻 14, 号 5, p. 4344-4348, 発行日 2018-05 |
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| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29067113 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/etm.2017.5052 | |||||
