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  1. 原著論文

Effects of irradiation on bone invasion of breast cancer cells

https://repo.qst.go.jp/records/48857
https://repo.qst.go.jp/records/48857
3bc5d496-22d2-44d4-b87a-33ea7da3f996
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-11
タイトル
タイトル Effects of irradiation on bone invasion of breast cancer cells
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Srimawong, Preeyaporn

× Srimawong, Preeyaporn

WEKO 927900

Srimawong, Preeyaporn

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Sawajiri, Masahiko

× Sawajiri, Masahiko

WEKO 927901

Sawajiri, Masahiko

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Terato, Hiroaki

× Terato, Hiroaki

WEKO 927902

Terato, Hiroaki

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Maruyama, Kouichi

× Maruyama, Kouichi

WEKO 927903

Maruyama, Kouichi

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Tanimoto, Keiji

× Tanimoto, Keiji

WEKO 927904

Tanimoto, Keiji

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Srimawong, Preeyaporn

× Srimawong, Preeyaporn

WEKO 927905

en Srimawong, Preeyaporn

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Masahiko, Sawajiri

× Masahiko, Sawajiri

WEKO 927906

en Masahiko, Sawajiri

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Hiroaki, Teratou

× Hiroaki, Teratou

WEKO 927907

en Hiroaki, Teratou

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Kouichi, Maruyama

× Kouichi, Maruyama

WEKO 927908

en Kouichi, Maruyama

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抄録
内容記述タイプ Abstract
内容記述 Background: Periostin is overexpressed in metastases from bone cancer. Many studies have indicated that periostin plays an important role in bone metastasis. Radiotherapy improves local tumor control, but recent evidence suggests that irradiation of the target tumor can promote tumor invasion and metastasis.
Objective: The purpose of the study was to examine the effects of irradiation with carbon ion or gamma ray on the expression of periostin in breast cancer cells and the cytokine levels of osteoblasts in bone tumor metastases.
Materials and methods: Breast cancer cells (FM3A/R cells) were exposed to carbon ion or gamma ray and then cocultured with non-irradiated osteoblastic MC3T3-E1 cells. Periostin expression in breast cancer cells and the levels of cytokines influencing bone invasion in osteoblastic cells were measured.
Results: Periostin expression increased after irradiation with carbon ion or gamma ray. Carbon ion-irradiated cells expressed less periostin than did gamma ray-irradiated cells. Carbon ion irradiation stimulated low levels of periostin synthesis than gamma ray irradiation. The cytokines influencing bone invasion levels rose in tandem with the increase in periostin level.
Conclusions: Carbon ion irradiation may reduce the production of bone-destroying cytokines and vascularization factors by osteoblasts in the microenvironment of cancer invasion in bone. A combination of carbon ion irradiation and a periostin inhibitor would improve treatment of bone metastatic breast cancer.
書誌情報 Journal of Thai Association of Radiation Oncology

巻 23, 号 2, p. 26-36, 発行日 2018-03
出版者
出版者 idesign
ISSN
収録物識別子タイプ ISSN
収録物識別子 0859-2616
DOI
識別子タイプ DOI
関連識別子 10.1016/S0915-6992(08)80031-3
関連サイト
識別子タイプ URI
関連識別子 https://www.thastro.org/wp-content/uploads/Vol.23.2-2560.pdf
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