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Effects of irradiation on bone invasion of breast cancer cells
https://repo.qst.go.jp/records/48857
https://repo.qst.go.jp/records/488573bc5d496-22d2-44d4-b87a-33ea7da3f996
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-11 | |||||
| タイトル | ||||||
| タイトル | Effects of irradiation on bone invasion of breast cancer cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Srimawong, Preeyaporn
× Srimawong, Preeyaporn× Sawajiri, Masahiko× Terato, Hiroaki× Maruyama, Kouichi× Tanimoto, Keiji× Srimawong, Preeyaporn× Masahiko, Sawajiri× Hiroaki, Teratou× Kouichi, Maruyama |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Periostin is overexpressed in metastases from bone cancer. Many studies have indicated that periostin plays an important role in bone metastasis. Radiotherapy improves local tumor control, but recent evidence suggests that irradiation of the target tumor can promote tumor invasion and metastasis. Objective: The purpose of the study was to examine the effects of irradiation with carbon ion or gamma ray on the expression of periostin in breast cancer cells and the cytokine levels of osteoblasts in bone tumor metastases. Materials and methods: Breast cancer cells (FM3A/R cells) were exposed to carbon ion or gamma ray and then cocultured with non-irradiated osteoblastic MC3T3-E1 cells. Periostin expression in breast cancer cells and the levels of cytokines influencing bone invasion in osteoblastic cells were measured. Results: Periostin expression increased after irradiation with carbon ion or gamma ray. Carbon ion-irradiated cells expressed less periostin than did gamma ray-irradiated cells. Carbon ion irradiation stimulated low levels of periostin synthesis than gamma ray irradiation. The cytokines influencing bone invasion levels rose in tandem with the increase in periostin level. Conclusions: Carbon ion irradiation may reduce the production of bone-destroying cytokines and vascularization factors by osteoblasts in the microenvironment of cancer invasion in bone. A combination of carbon ion irradiation and a periostin inhibitor would improve treatment of bone metastatic breast cancer. |
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| 書誌情報 |
Journal of Thai Association of Radiation Oncology 巻 23, 号 2, p. 26-36, 発行日 2018-03 |
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| 出版者 | ||||||
| 出版者 | idesign | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0859-2616 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/S0915-6992(08)80031-3 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.thastro.org/wp-content/uploads/Vol.23.2-2560.pdf | |||||
