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ATF7 mediates TNF-α–induced telomere shortening
https://repo.qst.go.jp/records/48833
https://repo.qst.go.jp/records/4883329fdd3dd-4da9-407b-8254-0e40af389987
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-02 | |||||
| タイトル | ||||||
| タイトル | ATF7 mediates TNF-α–induced telomere shortening | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Maekawa, Toshio
× Maekawa, Toshio× Liu, Binbin× Nakai, Daisuke× Yoshida, Keisuke× Ken-ichi, Nakamura× Yasukawa, Mami× 小池, 学× Takubo, Kaiyo× Chatton, Bruno× Ishikawa, Fuyuki× Masutomi, Kenkichi× Koike, Manabu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Telomeres maintain the integrity of chromosome ends and telomere length is an important marker of aging. The epidemiological studies suggested that many types of stress including psychosocial stress decrease telomere length. However, it remains unknown how various stresses induce telomere shortening. Here, we report that the stress-responsive transcription factor ATF7 mediates TNF-α–induced telomere shortening. ATF7 and telomerase, an enzyme that elongates telomeres, are localized on telomeres via interactions with the Ku complex. In response to TNF-α, which is induced by various stresses including psychological stress, ATF7 was phosphorylated by p38, leading to the release of ATF7 and telomerase from telomeres. Thus, a decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice. These findings give credence to the idea that various types of stress might shorten telomere. | |||||
| 書誌情報 |
Nucleic acids research 巻 46, 号 9, p. 4487-4504, 発行日 2018-02 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0305-1048 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/nar/gky1552 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky155/4911553 | |||||
