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Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes
https://repo.qst.go.jp/records/48832
https://repo.qst.go.jp/records/488326b1beded-6337-4e65-abf7-3a63d7679520
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-02 | |||||
| タイトル | ||||||
| タイトル | Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Morishita, Kosuke
× Morishita, Kosuke× Yuna, Okamoto× Murayama, Shuhei× Usui, Kazuteru× Eriko, Ohashi× Hirai, Go× Aoki, Ichio× Karasawa, Satoru× 村山 周平× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50–90 and ∼30–100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging. | |||||
| 書誌情報 |
Langmuir 巻 33, 号 31, p. 7810-7817, 発行日 2017-07 |
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| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28678510 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acs.langmuir.7b01126 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.7b01126 | |||||
| 関連名称 | http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.7b01126 | |||||
