{"_buckets": {"deposit": "e558f082-a796-414f-8ef2-88ad082616ca"}, "_deposit": {"created_by": 1, "id": "48786", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48786"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048786", "sets": ["1"]}, "author_link": ["733686", "733688", "733681", "733689", "733682", "733687", "733685", "733684", "733683"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "561", "bibliographicPageStart": "552", "bibliographicVolumeNumber": "265", "bibliographic_titles": [{"bibliographic_title": "Journal of Neurology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "There is no reliable objective indicator for upper motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). To\ndetermine the clinical significance and potential utility of magnetic resonance (MR) signals, we investigated the relationship\nbetween clinical symptoms and susceptibility changes in the motor cortex measured using susceptibility-weighted MR\nimaging taken by readily available 3-T MRI in clinical practice. Twenty-four ALS patients and 14 control subjects underwent\n3-T MR T1-weighted imaging and susceptibility-weighted MR imaging with the principles of echo-shifting with a train of\nobservations (PRESTO) sequence. We analysed relationships between relative susceptibility changes in the motor cortex\nassessed using voxel-based analysis (VBA) and clinical scores, including upper motor neuron score, ALS functional rating\nscale revised score, and Medical Research Council sum score on physical examination. Patients with ALS exhibited significantly\nlower signal intensity in the precentral gyrus on susceptibility-weighted MR imaging compared with controls. Clinical\nscores were significantly correlated with susceptibility changes. Importantly, the extent of the susceptibility changes in the\nbilateral precentral gyri was significantly correlated with upper motor neuron scores. The results of our pilot study using\nVBA indicated that low signal intensity in motor cortex on susceptibility-weighted MR imaging may correspond to clinical\nsymptoms, particularly upper motor neuron dysfunction. Susceptibility-weighted MR imaging may be a useful diagnostic\ntool as an objective indicator of upper motor neuron dysfunction.", "subitem_description_type": "Abstract"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "29356968", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00415-017-8728-0", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0340-5354 ", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Endo, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "733681", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sekiguchi, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "733682", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "733683", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Takehiro"}], "nameIdentifiers": [{"nameIdentifier": "733684", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kowa, Hisatomo"}], "nameIdentifiers": [{"nameIdentifier": "733685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanda, Fumio"}], "nameIdentifiers": [{"nameIdentifier": "733686", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toda, Tatsushi"}], "nameIdentifiers": [{"nameIdentifier": "733687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "733688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "733689", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48786", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-03-05"}, "publish_date": "2018-03-05", "publish_status": "0", "recid": "48786", "relation": {}, "relation_version_is_last": true, "title": ["Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study"], "weko_shared_id": -1}