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Rational design of [13C,D14]tert-butylbenzene as a scaffold structure for designing long-lived hyperpolarized 13C probes
https://repo.qst.go.jp/records/48783
https://repo.qst.go.jp/records/487837de46211-96c0-4005-a9b2-4b5f9ec1b23d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-23 | |||||
| タイトル | ||||||
| タイトル | Rational design of [13C,D14]tert-butylbenzene as a scaffold structure for designing long-lived hyperpolarized 13C probes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imakura, Yuki
× Imakura, Yuki× Nonaka, Hiroshi× Takakusagi, Yoichi× Ichikawa, Kazuhiro× Maptue, Nesmine× Funk, Alexander× Khemtong, Chalermchai× Sando, Shinsuke× 高草木 洋一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dynamic nuclear polarization (DNP) is a technique to polarize the nuclear spin population. As a result of the hyperpolarization, NMR sensitivity of the nuclei in molecules can be enhanced dramatically. Recent application of the hyperpolarization technique has led to advances in biochemical and molecular studies. A major problem is the short lifetime of the polarized nuclear spin state. Generally, in solution, the polarized nuclear spin state decays to a thermal spin equilibrium, resulting in loss of the enhanced NMR signal. This decay is correlated directly with the spin-lattice relaxation time T1. Here we report [13C,D14]tert-butylbenzene as a new scaffold structure for designing hyperpolarized 13C probes. Thanks to the minimized spin-lattice relaxation (T1) pathways, its water-soluble derivative showed a remarkably long 13C T1 value and long retention of the hyperpolarized spin state. | |||||
| 書誌情報 |
Chemistry − An Asian Journal 巻 13, 発行日 2017-12 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1861-4728 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29291256 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/asia.201701652 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://onlinelibrary.wiley.com/doi/10.1002/asia.201701652/abstract;jsessionid=9277AA92244DE0A79DFD76598EBFB6B4.f01t01 | |||||
| 関連名称 | http://onlinelibrary.wiley.com/doi/10.1002/asia.201701652/abstract;jsessionid=9277AA92244DE0A79DFD76598EBFB6B4.f01t01 | |||||
