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Circular dichroism spectroscopic study on structural alterations of histones induced by post-translational modifications in DNA damage responses: Lysine-9 methylation of H3
https://repo.qst.go.jp/records/48766
https://repo.qst.go.jp/records/487666680e9de-346e-4144-8abd-0b37e43d48e9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-20 | |||||
| タイトル | ||||||
| タイトル | Circular dichroism spectroscopic study on structural alterations of histones induced by post-translational modifications in DNA damage responses: Lysine-9 methylation of H3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Izumi, Yudai
× Izumi, Yudai× Mastuo, Koichi× Fujii, Kentaro× Yokoya, Akinari× Taniguchi, Masaki× Namatame, Hirofumi× 藤井 健太郎× 横谷 明徳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report the global structural alterations in histone H3 proteins induced by lysine-9 mono-, di- and trimethylation, which are part of the critical post-translational modifications for DNA damage responses, identified using synchrotron radiation circular dichroism (CD) spectroscopy. Compared with unmodified H3, mono- and dimethylation increases the number of α-helices and decreases the numbers of β-strands, while trimethylation decreases the α-helix content and increases the β-strand content. Comparison of the secondary-structure contents of these histone H3 proteins suggests that the methylation-induced structural alterations occur at residues not only close to but also distant from the methylated sites. Such global structural alterations may regulate the interactions of methylated histones with other molecules, such as histone-binding proteins in DNA damage repair processes. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 59, 号 7, 発行日 2017-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29244169 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrx068 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/jrr/advance-article/doi/10.1093/jrr/rrx068/4721796#104883643 | |||||
| 関連名称 | https://academic.oup.com/jrr/advance-article/doi/10.1093/jrr/rrx068/4721796#104883643 | |||||
