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Efficient Protective Activity of a Planar Catechin Analogue against Radiation-Induced Apoptosis in Rat Thymocytes
https://repo.qst.go.jp/records/48688
https://repo.qst.go.jp/records/48688d9610ea3-3528-43b1-987b-c302ef9f72ad
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-07 | |||||
| タイトル | ||||||
| タイトル | Efficient Protective Activity of a Planar Catechin Analogue against Radiation-Induced Apoptosis in Rat Thymocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Emiko, Sekine-Suzuki
× Emiko, Sekine-Suzuki× Nakanishi, Ikuo× Imai, Kohei× Ueno, Megumi× Shimokawa, Takashi× Ken-ichiro, Matsumoto× Fukuhara, Kiyoshi× Sekine, Emiko× Nakanishi, Ikuo× Imai, Kohei× Ueno, Megumi× Shimokawa, Takashi× Matsumoto, Kenichiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | About two thirds of biological damage due to low linear energy transfer (LET) radiation, such as X-rays and the plateau region of heavy-ion beams, is known to be caused by the hydroxyl radical, the most powerful reactive oxygen species (ROS), generated via ionisation and excitation of water molecules. Thus, compounds having an efficient scavenging activity against ROS are expected to exhibit a radio protective activity. A planar catechin analogue, where an isopropyl fragment was introduced into the catechol ring (B ring) of (+)-catechin, showed an efficient protective effect against X-ray induced apoptosis in rat thymocytes compared to (+)-catechin. The plane catechin scavenged 2,2-diphenyl-1-picrylhydrazyl radical solubilised in water by beta-cyclodextrin about 10-fold faster than (+)-catechin in phosphate buffer (0.1 M, pH 7.4) at 298 K. Furthermore, the experimental log P value of the planar catechin (1.22) is reported to be significantly larger than that of (+)-catechin (0.44). The higher radical-scavenging activity and lipophilicity of the planar catechin than those of (+)-catechin may contribute in part to the higher protective activity against X-ray-induced apoptosis in rat thymocytes. | |||||
| 書誌情報 |
RSC Advances 巻 8, 号 19, p. 10158-10162, 発行日 2018-03 |
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| 出版者 | ||||||
| 出版者 | The Royal Society of Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2046-2069 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/C7RA13111A | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://pubs.rsc.org/en/Content/ArticleLanding/2018/RA/C7RA13111A | |||||
