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In vivo tau imaging for a diagnostic platform of tauopathy using the rTg4510 mouse line
https://repo.qst.go.jp/records/48687
https://repo.qst.go.jp/records/48687da1e80eb-3696-4b52-9052-cef5ef5dcea8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-08 | |||||
| タイトル | ||||||
| タイトル | In vivo tau imaging for a diagnostic platform of tauopathy using the rTg4510 mouse line | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sahara, Naruhiko
× Sahara, Naruhiko× Shimojo, Masafumi× Ono, Maiko× Takuwa, Hiroyuki× Marcelo, Febo× Higuchi, Makoto× Suhara, Tetsuya× 佐原 成彦× 下條 雅文× 小野 麻衣子× 田桑 弘之× 樋口 真人× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Association of tau deposition with neurodegeneration in Alzheimer’s disease (AD) and related tau-positive neurological disorders collectively referred to as tauopathies indicates contribution of tau aggregates to neurotoxicity. The discovery of tau gene mutations in FTDP-17-tau kindreds has provided unequivocal evidence that tau abnormalities alone can induce neurodegenerative disorders. Therefore, visualization of tau accumulation would offer a reliable, objective index to aid in the diagnosis of tauopathy and to assess the disease progression. Positron emission tomography (PET) imaging of tau lesions is currently available using several tau PET ligands. Because most tau PET ligands have the property of an extrinsic fluorescent dye, these ligands are considered to be useful for both PET and fluorescence imaging. In addition, small-animal magnetic resonance imaging (MRI) is available for both structural and functional imaging. Using these advanced imaging techniques, in vivo studies on a mouse model of tauopathy will provide significant insight into the translational research of neurodegenerative diseases. In this review, we will discuss the utilities of PET, MRI and fluorescence imaging for evaluating the disease progression of tauopathy. | |||||
| 書誌情報 |
Frontiers in Neurology 巻 8, 号 663, 発行日 2017-12 |
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| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29375461 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fneur.2017.00663 | |||||
