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However, little is known about such distribution in aging brains and mild cognitive impairment (MCI) brains.\nMethods Cognitive functions and regional accumulation of tau and amyloid (A) were evaluated in 13 healthy controls (HCs), 3 patients with MCI, and 4 AD patients. Tau and A accumulation was semi-quantitatively measured with positron emission tomography (PET) using [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB).\nResults Age-dependent accumulation of tau was found in all predetermined regions characteristic of AD, especially in the parahippocampal gyrus, lateral temporal cortex, frontal cortex, and posterior cingulate gyrus, where age-dependency was statistically significant. In contrast, age-dependency in accumulation of A was not observed in most regions assessed in HC. 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  1. 原著論文

Localized accumulation of tau without amyloid-beta in aged brains measured with [11C]PBB3 and [11C]PiB positron emission tomography

https://repo.qst.go.jp/records/48686
https://repo.qst.go.jp/records/48686
6b0fec63-ef61-42b6-af68-1c9e0c1bd58e
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-04-08
タイトル
タイトル Localized accumulation of tau without amyloid-beta in aged brains measured with [11C]PBB3 and [11C]PiB positron emission tomography
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Kikukawa, Takayuki

× Kikukawa, Takayuki

WEKO 489839

Kikukawa, Takayuki

Search repository
Saito, Haruna

× Saito, Haruna

WEKO 489840

Saito, Haruna

Search repository
Hasegawa, Itsuki

× Hasegawa, Itsuki

WEKO 489841

Hasegawa, Itsuki

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Takeuchi, Jun

× Takeuchi, Jun

WEKO 489842

Takeuchi, Jun

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Takeda, Akitoshi

× Takeda, Akitoshi

WEKO 489843

Takeda, Akitoshi

Search repository
Kawabe, Joji

× Kawabe, Joji

WEKO 489844

Kawabe, Joji

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Wada, Yasuhiro

× Wada, Yasuhiro

WEKO 489845

Wada, Yasuhiro

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Mawatari, Aya

× Mawatari, Aya

WEKO 489846

Mawatari, Aya

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Watanabe, Yasuyoshi

× Watanabe, Yasuyoshi

WEKO 489847

Watanabe, Yasuyoshi

Search repository
Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 489848

Kitamura, Soichiro

Search repository
Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 489849

Shimada, Hitoshi

Search repository
Higuchi, Makoto

× Higuchi, Makoto

WEKO 489850

Higuchi, Makoto

Search repository
Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 489851

Suhara, Tetsuya

Search repository
Itoh, Yoshiaki

× Itoh, Yoshiaki

WEKO 489852

Itoh, Yoshiaki

Search repository
島田 斉

× 島田 斉

WEKO 489853

en 島田 斉

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樋口 真人

× 樋口 真人

WEKO 489854

en 樋口 真人

Search repository
須原 哲也

× 須原 哲也

WEKO 489855

en 須原 哲也

Search repository
抄録
内容記述タイプ Abstract
内容記述 Objective Different regional specificity in tau accumulation is well known in Alzheimer’s disease (AD) brains. However, little is known about such distribution in aging brains and mild cognitive impairment (MCI) brains.
Methods Cognitive functions and regional accumulation of tau and amyloid (A) were evaluated in 13 healthy controls (HCs), 3 patients with MCI, and 4 AD patients. Tau and A accumulation was semi-quantitatively measured with positron emission tomography (PET) using [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB).
Results Age-dependent accumulation of tau was found in all predetermined regions characteristic of AD, especially in the parahippocampal gyrus, lateral temporal cortex, frontal cortex, and posterior cingulate gyrus, where age-dependency was statistically significant. In contrast, age-dependency in accumulation of A was not observed in most regions assessed in HC. Moreover, the accumulation of tau in regions characteristic of AD in MCI patients were higher than that in HC, whereas tau accumulation was highest and statistically significant in AD patients. Unlike HC, the accumulation of tau was accompanied by that of Ain patients with MCI and AD.
Conclusion Mild and age-dependent accumulation of tau without A was found in AD-related areas in aging brains. Considering age as a major risk for AD, higher accumulation of tau may trigger the neurodegenerative process of AD.
書誌情報 Journal of Alzheimer's Disease & Parkinsonism

巻 7, 号 6, 発行日 2017-11
ISSN
収録物識別子タイプ ISSN
収録物識別子 2161-0460
DOI
識別子タイプ DOI
関連識別子 10.4172/2161-0460.1000401
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