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Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male
https://repo.qst.go.jp/records/48685
https://repo.qst.go.jp/records/486859d12c394-6f74-44d1-be93-4d594e4e3966
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-08 | |||||
| タイトル | ||||||
| タイトル | Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Barron, Anna
× Barron, Anna× Ji, Bin× Kito, Seiji× Suhara, Tetsuya× Higuchi, Makoto× Ｂａｒｒｏｎ Ａｎｎａ× 季 斌× 鬼頭 靖司× 須原 哲也× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The translocator protein (TSPO) has been proposed to act as a key component in a complex important for mitochondrial cholesterol importation, which is the rate-limiting step in steroid hormone synthesis. However, TSPO function in steroidogenesis has recently been challenged by the development of TSPO knockout (TSPO-KO) mice, as they exhibit normal baseline gonadal testosterone and adrenal corticosteroid production. Here we demonstrate that despite normal androgen levels in young male TSPO-KO mice, TSPO deficiency alters steroidogenic flux and results in reduced total steroidogenic output. Specific reductions in levels of progesterone and corticosterone were observed in both young and aged male TSPO-KO mice, as well as age-dependent androgen deficiency. Collectively, these findings indicate that while TSPO is not critical for achieving baseline testicular and adrenal steroidogenesis, either indirect effects of TSPO on steroidogenic processes, or the presence of compensatory mechanisms and functional redundancy, lead to subtle steroidogenic abnormalities which become exacerbated with aging. | |||||
| 書誌情報 |
Biochemical Journal 巻 475, 号 1, p. 75-85, 発行日 2017-11 |
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| 出版者 | ||||||
| 出版者 | Published by Portland Press on behalf of the Biochemical Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0264-6021 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29127254 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1042/BCJ20170645 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.biochemj.org/content/early/2017/11/10/BCJ20170645.long | |||||
| 関連名称 | http://www.biochemj.org/content/early/2017/11/10/BCJ20170645.long | |||||
