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Crystal structure of the overlapping dinucleosome composed of hexasome and octasome
https://repo.qst.go.jp/records/48622
https://repo.qst.go.jp/records/48622c5ce6318-6d3e-49be-84ad-7a35fd9360e8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-23 | |||||
| タイトル | ||||||
| タイトル | Crystal structure of the overlapping dinucleosome composed of hexasome and octasome | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Daiki
× Kato, Daiki× Osakabe, Akihisa× Arimura, Yasuhiro× Mizukami, Yuka× Horikoshi, Naoki× Saikusa, Kazumi× Akashi, Satoko× Nishimura, Yoshifumi× Park, Sam-Yong× Nogami, Jumpei× Kazumitsu, Maehara× Ohkawa, Yasuyuki× Matsumoto, Atsushi× Kono, Hidetoshi× Rintaro, Inoue× Sugiyama, Masaaki× Kurumizaka, Hitoshi× 松本 淳× 河野 秀俊 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nucleosomes are dynamic entities that are repositioned along DNA by chromatin remodeling processes. A nucleosome repositioned by the switch-sucrose nonfermentable (SWI/SNF) remodeler collides with a neighbor and forms the intermediate “overlapping dinucleosome.” Here, we report the crystal structure of the overlapping dinucleosome, in which two nucleosomes are associated, at 3.14-angstrom resolution. In the overlapping dinucleosome structure, the unusual “hexasome” nucleosome, composed of the histone hexamer lacking one H2A-H2B dimer from the conventional histone octamer, contacts the canonical “octasome” nucleosome, and they intimately associate. Consequently, about 250 base pairs of DNA are left-handedly wrapped in three turns, without a linker DNA segment between the hexasome and octasome moieties. The overlapping dinucleosome structure may provide important information to understand how nucleosome repositioning occurs during the chromatin remodeling process. | |||||
| 書誌情報 |
Science 巻 356, 号 6334, p. 205-208, 発行日 2017-04 |
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| 出版者 | ||||||
| 出版者 | AAAS | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0036-8075 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28408607 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1126/science.aak9867 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | 1095-9203 | |||||
| 関連名称 | 1095-9203 | |||||
