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A significant role of non-thermal equilibrated electrons in the formation of deleterious complex DNA damage
https://repo.qst.go.jp/records/48594
https://repo.qst.go.jp/records/4859491db1db2-772d-4a97-87a4-3471e5233639
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-19 | |||||
| タイトル | ||||||
| タイトル | A significant role of non-thermal equilibrated electrons in the formation of deleterious complex DNA damage | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kai, Takeshi
× Kai, Takeshi× Yokoya, Akinari× Ukai, Masatoshi× Fujii, Kentaro× Toigawa, Tomohiro× Watanabe, Rituko× 横谷 明徳× 横谷 立子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is thought that complex DNA damage which induces in radiation biological effects is formed at radiation track end. Thus, the earliest stage of water radiolysis at the electron track end was studied to predict DNA damage. These results indicate that DNA damage sites comprising multiple nucleobase lesions with a single strand breaks can therefore be formed by multiple collisions of the electrons within three base pairs (3bp) of a DNA strand. This multiple damage site cannot be processed by base excision repair enzymes. However, pre-hydrated electrons can also be produced resulting in an additional base lesion more than 3bp away from the multi-damage site. This clustered damage site may be finally converted into a double strand break (DSB) when base excision enzymes process the additional base lesions. These DSBs include another base lesion(s) at their termini that escape from the base excision process and which may result in biological effects such as mutation in surviving cells. | |||||
| 書誌情報 |
Physical Chemistry Chemical Physics 巻 20, 号 4, p. 2838-2844, 発行日 2018-01 |
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| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/C7CP06903K | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1039/C7CP06903K | |||||
| 関連名称 | https://doi.org/10.1039/C7CP06903K | |||||
