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Roles of Mitochondria-Generated Reactive Oxygen Species on X-ray-Induced Apoptosis in a Human Hepatocellular Carcinoma Cell Line, HLE
https://repo.qst.go.jp/records/48533
https://repo.qst.go.jp/records/4853379c456ed-e3fd-420a-adeb-42036fcc8dd6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-20 | |||||
| タイトル | ||||||
| タイトル | Roles of Mitochondria-Generated Reactive Oxygen Species on X-ray-Induced Apoptosis in a Human Hepatocellular Carcinoma Cell Line, HLE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Indo, Hiroko
× Indo, Hiroko× Inanami, Osamu× Koumura, Tomoko× Suenaga, Shigeaki× Yen, Hsiu-Chuan× Kakinuma, Shizuko× Matsumoto, Kenichiro× Nakanishi, Ikuo× St, Clair William× K., St Clair Daret× Matsui, Hirofumi× Cornette, Richard× Gusev, Oleg× Okuda, Takashi× Nakagawa, Yasuhito× Ozawa, Toshihiko× Majima, Hideyuki× 柿沼 志津子× 松本 謙一郎× 中西 郁夫× 松井 裕史× 小澤 俊彦× 馬嶋 秀行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | HLE, a human hepatocellular carcinoma cell line was transiently transfected with normal human MnSOD and MnSOD without a mitochondrial target signal (MTS). Mitochondrial reactive oxygen species (ROS), lipid peroxidation and apoptosis were examined as a function of time following 18.8 Gy X-ray irradiation. Our results showed that the level of mitochondrial ROS increased and reached a maximum level 2 hours after X-ray irradiation. Authentic MnSOD, but not MnSOD lacking MTS, protected against mitochondrial ROS, lipid peroxidation and apoptosis. In addition, the levels of mitochondrial ROS were consistently found to always correlate with the levels of authentic MnSOD in mitochondria. These results suggest that only when MnSOD is located in mitochondria is it efficient in protecting against cellular injuries by X-ray irradiation and that mitochondria are the critical sites of X-ray-induced cellular oxidative injuries. | |||||
| 書誌情報 |
Free Radical Research 巻 46, 号 8, p. 1029-1043, 発行日 2012-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1071-5762 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3109/10715762.2012.698012 | |||||
