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Impressive Suppression of Colon Cancer Growth by Triple Combination SN38/EF24/Melatonin: "Oncogenic" Versus "Onco-Suppressive" Reactive Oxygen Species.
https://repo.qst.go.jp/records/48516
https://repo.qst.go.jp/records/4851637543f8b-ae9e-4830-8908-5e3f99a74a23
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-15 | |||||
| タイトル | ||||||
| タイトル | Impressive Suppression of Colon Cancer Growth by Triple Combination SN38/EF24/Melatonin: "Oncogenic" Versus "Onco-Suppressive" Reactive Oxygen Species. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
BAKALOVA, RUMIANA
× BAKALOVA, RUMIANA× ZHELEV, ZHIVKO× SAYAKA, SHIBATA× NIKOLOVA, BILIANA× AOKI, ICHIO× HIGASHI, TATSUYA× バカロバ ルミアナ× 柴田 さやか× 青木 伊知男× 東 達也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: The study aimed to investigate the effect of multi-targeted combinations (SN38/EF24; SN38/EF24/melatonin) on the growth of colon cancer in experimental animals and their impact on the ratio “oncogenic”/“onco-suppressive” reactive oxygen species (ROS) – a crucial factor for triggering carcinogenesis, as well as for development of effective therapeutic strategies. Materials and Methods: The experiments were conducted on colon cancer-grafted mice – non-treated, SN38/EF24-treated and SN38/EF24/melatonin-treated within 22 days. The balance between different types of ROS was measured in vivo by nitroxide-enhanced magnetic resonance imaging (MRI), as well as on isolated tissue specimens by conventional analytical tests. Results: Both combinations significantly suppressed the tumor growth. Impressive anticancer effect was observed in SN38/EF24/melatonin-treated mice – almost complete destruction of the tumor. Both types of ROS (superoxide and hydroperoxides) were elevated in cancer, but the MRI data suggest that the ratio between them tends towards superoxide. SN38/EF24 decreased the level of superoxide, but did not affect the level of hydroperoxides in the cancerous tissue, while SN38/EF24/melatonin decreased the level of superoxide below the control and increased significantly the level of hydroperoxides. Conclusion: The most important observations are that: (i) colon cancer was characterized by a vicious cycle, that ensures a permanent domination of “oncogenic” ROS (as superoxide) over “onco-suppressive” ROS (as hydrogen peroxide); (ii) the anticancer effect of the triple combination EF24/SN38/melatonin was accompanied by decreasing “oncogenic” and increasing “onco-suppressive” ROS; (iii) the ratio between both types of ROS could be a new onco-target for combined therapy; and (iv) nitroxide-enhanced MRI is a valuable tool for analyzing of this ratio. | |||||
| 書誌情報 |
Anticancer research 巻 37, 号 10, p. 5449-5458, 発行日 2017-10 |
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| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28982855 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21873/anticanres.11973 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ar.iiarjournals.org/content/37/10/5449.abstract | |||||
| 関連名称 | http://ar.iiarjournals.org/content/37/10/5449.abstract | |||||
