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Dosimetric Variation Due to CT Inter-Slice Spacing in Four-Dimensional Carbon Beam Lung Therapy
https://repo.qst.go.jp/records/48432
https://repo.qst.go.jp/records/4843233d42cd4-c395-4c74-9b1b-ee5e197c5836
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-11 | |||||
| タイトル | ||||||
| タイトル | Dosimetric Variation Due to CT Inter-Slice Spacing in Four-Dimensional Carbon Beam Lung Therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kumagai, Motoki
× Kumagai, Motoki× Mori, Shinichiro× Gregory, Sharp× Asakura, Hiroshi× Kandatsu, Susumu× Endo, Masahiro× Baba, Masayuki× 熊谷 始紀× 森 慎一郎× 浅倉 裕史× 神立 進× 遠藤 真広× 馬場 雅行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: When CT data with a thick slice thickness are used in treatment planning, geometrical uncertainty may induce dosimetric errors. We evaluated carbon ion dose variations due to different CT slice thicknesses using a four-dimensional (4D) carbon ion beam dose calculation, and compared results between ungated and gated respiratory strategies. Material and Methods: Seven lung patients were scanned in 4D mode with a 0.5-mm slice thickness using a 256-multi-slice CT scanner. CT images were averaged with various numbers of images to simulate reconstructed images with various slice thicknesses (0.5 mm-5.0 mm). Two scenarios were studied (respiratory-ungated and -gated strategies). Range compensators were designed for each of the CT volumes with coarse inter-slice spacing to cover the internal target volume (ITV), as defined from 4DCT. Carbon ion dose distribution was computed for each resulting ITV on the 0.5-mm slice 4DCT data. The accumulated dose distribution was then calculated using deformable registration for 4D dose assessment. Results: The magnitude of over- and under-dosage was found to be larger with the use of range compensators designed with a coarser inter-slice spacing than those obtained with a 0.5-mm slice thickness. Although no under dosage was observed within the clinical target volume (CTV) region, D95 remained at over 97% of the prescribed dose for the ungated strategy and 95% for the gated strategy for all slice thickness. Inter-slice spacing of less than 3 mm may be able minimize dose variation between the ungated and gated strategies. Conclusions: Although volumes with increased inter-slice spacing may reduce geometrical accuracy at a certain respiratory phase, this does not significantly affect delivery of the accumulated dose to the target during the treatment course. |
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| 書誌情報 |
Physics in Medicine and Biology 巻 54, 号 10, p. 3231-3246, 発行日 2009-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
