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Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model
https://repo.qst.go.jp/records/48423
https://repo.qst.go.jp/records/484234b04f733-060d-4b81-85db-5a94a34792bd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-11 | |||||
| タイトル | ||||||
| タイトル | Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takashima, Hiroki
× Takashima, Hiroki× Tsuji, Atsushi× Saga, Tsuneo× Yasunaga, Masahiro× Koga, Yoshikatsu× Kuroda, Jun-ichiro× Yano, Shigetoshi× Kuratsu, Jun-ichi× Matsumura, Yasuhiro× 辻 厚至× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nuclear medicine examinations for imaging gliomas have been introduced into clinical practice to evaluate the grade of malignancy and determine sampling locations for biopsies. However, these modalities have some limitations. Tissue factor (TF) is overexpressed in various types of cancers, including gliomas. We thus generated an anti-human TF monoclonal antibody (mAb) clone 1849. In the present study, immunohistochemistry performed on glioma specimens using anti-TF 1849 mAb showed that TF expression in gliomas increased in proportion to the grade of malignancy based on the World Health Organization (WHO) classification, and TF was remarkably expressed in necrosis and pseudopalisading cells, the histopathological hallmarks of glioblastoma multiforme (GBM). Furthermore, in both fluorescence and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging studies, anti-TF 1849 IgG efficiently accumulated in TF-overexpressing intracranial tumours in mice. Although further investigation is required for a future clinical use of immuno-SPECT with 111In-labelled anti-TF 1849 IgG, the immuno-SPECT may represent a unique imaging modality that can visualize the biological characteristics of gliomas differently from those obtained using the existing imaging modalities and may be useful to evaluate the grade of malignancy and determine sampling locations for biopsies in patients with glioma, particularly GBM. | |||||
| 書誌情報 |
Scientific Reports 巻 7, p. 12341-1-12341-13, 発行日 2017-09 |
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| 出版者 | ||||||
| 出版者 | Nature | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28951589 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-017-12563-5 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/28951589?dopt=Abstract | |||||
| 関連名称 | https://www.ncbi.nlm.nih.gov/pubmed/28951589?dopt=Abstract | |||||
