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Generating and grading the abscopal effect: proposal for comprehensive evaluation of combination immunoradiotherapy in mouse models
https://repo.qst.go.jp/records/48418
https://repo.qst.go.jp/records/484185bbd5c04-9c07-4eeb-a73f-1ab267a858f5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-12-27 | |||||
| タイトル | ||||||
| タイトル | Generating and grading the abscopal effect: proposal for comprehensive evaluation of combination immunoradiotherapy in mouse models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ebner, Daniel
× Ebner, Daniel× Tinganelli, Walter× Helm, Alexander× Bisio, Alessandra× Simoniello, Palma× Natale, Francesco× Yamada, Shigeru× Kamada, Tadashi× Shimokawa, Takashi× Durante, Marco× エブナー ダニエル× Ｔｉｎｇａｎｅｌｌｉ Ｗａｌｔｅｒ× Ｎａｔａｌｅ Ｆｒａｎｃｅｓｃｏ× 山田 滋× 鎌田 正× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Numerous published case reports and forthcoming clinical trials combine immunotherapy and radiotherapy with the goal of demonstrating an abscopal effect reaction. However, reports and results are varied, and a comprehensive animal study combining radiotherapy modalities and immunotherapy agents has yet to be performed. Further, clinical reports are mixed, with inconsistent generation of the effect as well as abscopal effects seen ranging from widespread disease elimination to growth stagnation of local lymph node metastasis. We propose a grading system for use in differentiating abscopal effects seen in animal and clinical trials. Further, we will conduct a comprehensive study in mice, evaluating three radiotherapeutic modalities (photon, proton, and carbon-ion) combined with five immunotherapeutic agents with differing actions. Comprehensive cell analysis will be conducted with the aim of improving upon draft models of abscopal effect generation, as well as differentiating between locoregional and systemic methods of action. Further, evaluation of radiation fractionation, as well as combination with ex vivo activated dendritic cell (DC) inoculation, will be performed. Though the abscopal effect has been reported for nearly 70 years, only recently has delineation of its mechanism seemed possible. Comprehensive evaluation of available modalities may shed light on the precise requirements for generating the effect, potentially enabling its regular usage in the treatment of disease. | |||||
| 書誌情報 |
Translational Cancer Research 巻 6, 号 suppl5, p. S892-S899, 発行日 2017-05 |
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| 出版者 | ||||||
| 出版者 | AME Publishing Company | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2218-676x | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21037/tcr.2017.06.01 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.21037/tcr.2017.06.01 | |||||
| 関連名称 | http://dx.doi.org/10.21037/tcr.2017.06.01 | |||||
