A Multicenter Study of Carbon-Ion Radiation Therapy for Head and Neck Adenocarcinoma

Purpose: Head and neck (HN) adenocarcinoma is rare, and to date, there have been no
reports of prospective studies. We retrospectively evaluated the efficacy and safety of
carbon-ion radiation therapy (C-ion RT) for HN adenocarcinoma in institutions in
Japan.
Methods and Materials: HN adenocarcinoma patients with N0M0 or N1M0 disease
who were treated with C-ion RT at institutions in Japan between November 2003
and December 2014 were analyzed retrospectively. We enrolled 47 patients (30 male
and 17 female patients; median age, 60 years) with HN adenocarcinoma.
Results: Primary sites included the nasal and paranasal sinus in 21 patients, orbit in
11, salivary grand in 7, oral cavity and pharynx in 6, and acoustic organ in 2.
Thirty-two patients had T4 tumors, 6 had T3, and 6 had T2. Forty-five patients
received a diagnosis of N0 disease, whereas 2 had N1 disease. The median total dose
of C-ion RT and the number of fractions were 64.0 Gy (relative biological effectiveness)
and 16 fractions, respectively. The median follow-up period was 51 months
(range, 6-118 months). The 2- and 5-year overall survival rates were 87.9% and
60.4%, respectively, and the 2- and 5-year local control rates were 83.3% and
79.3%, respectively. Multivariate analysis showed that operability (patients with
operable tumors) (PZ.045) and fractionation (16 fractions) (PZ.010) were significant independent prognostic factors for better overall survival. No grade 5 late morbidities
were observed. Grade 4 late morbidities were observed in 4 patients, and all of
these grade 4 morbidities were visual impairments. All 4 patients with grade 4 visual
impairment had T4 tumors in the nasopharynx or paranasal sinuses, which implied
inoperable tumors with orbital or brain invasion.

書誌情報

Int J Radiation Oncol Biol Phys

巻 99, 号 2, p. 442-449, 発行日 2017-05

出版者

Elsevier Inc

ISSN

収録物識別子タイプ

ISSN

収録物識別子

0360-3016

PubMed番号

識別子タイプ

PMID

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2023-05-15 23:29:02.656846

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