WEKO3
アイテム
Ligation-Dependent Picosecond Dynamics in Human Hemoglobin as Revealed by Quasielastic Neutron Scattering
https://repo.qst.go.jp/records/48344
https://repo.qst.go.jp/records/483449c0f576f-3db8-46f5-8b37-f679e62bd548
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-05 | |||||
| タイトル | ||||||
| タイトル | Ligation-Dependent Picosecond Dynamics in Human Hemoglobin as Revealed by Quasielastic Neutron Scattering | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujiwara, Satoru
× Fujiwara, Satoru× 茶竹俊行(京都大学原子炉実験所)× Matsuo, Tatsuhito× Kono, Fumiaki× 富永大輝(総合科学技術機構)× 柴田薫(J-PARCセンター)× 佐藤文菜(自治医科大学)× 柴山修哉(自治医科大学)× 藤原 悟× 松尾 龍人× 河野 史明 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hemoglobin (Hb) is a prototypical allosteric protein. We investigated the picosecond dynamics of the deoxy and CO forms of human hemoglobin using quasielastic neutron scattering to extract the dynamics changes upon ligation. From the analysis of the global motions, we found that, whereas the deoxy-form can be described by assuming translational and rotational diffusion of a rigid body, those of the CO form need to involve an additional contribution of internal large-scale motions. We also found that the local dynamics in the deoxy and CO forms are very similar in amplitude, but are slightly lower in frequency in the former than in the latter. Our results reveal the presence of rapid large-scale motions in hemoglobin, and further demonstrate that this internal mobility is governed allosterically by the ligation state of the heme group. | |||||
| 書誌情報 |
Journal of Physical Chemistry B 巻 121, 号 34, p. 8069-8077, 発行日 2017-08 |
|||||
| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acs.jpcb.7b05182 | |||||
