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  1. 原著論文

In-room computed tomography-based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study.

https://repo.qst.go.jp/records/48314
https://repo.qst.go.jp/records/48314
b65828f2-0ad3-40f1-ab5d-07e1bc9767c3
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-21
タイトル
タイトル In-room computed tomography-based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Ohno, Tatsuya

× Ohno, Tatsuya

WEKO 485524

Ohno, Tatsuya

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Noda, Shin-Ei

× Noda, Shin-Ei

WEKO 485525

Noda, Shin-Ei

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Okonogi, Noriyuki

× Okonogi, Noriyuki

WEKO 485526

Okonogi, Noriyuki

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Murata, Kazutoshi

× Murata, Kazutoshi

WEKO 485527

Murata, Kazutoshi

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Shibuya, Kei

× Shibuya, Kei

WEKO 485528

Shibuya, Kei

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Kiyohara, Hiroki

× Kiyohara, Hiroki

WEKO 485529

Kiyohara, Hiroki

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Tamaki, Tomoaki

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WEKO 485530

Tamaki, Tomoaki

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Ando, Ken

× Ando, Ken

WEKO 485531

Ando, Ken

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Oike, Takahiro

× Oike, Takahiro

WEKO 485532

Oike, Takahiro

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Ohkubo, Yu

× Ohkubo, Yu

WEKO 485533

Ohkubo, Yu

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Wakatsuki, Masaru

× Wakatsuki, Masaru

WEKO 485534

Wakatsuki, Masaru

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Saitoh, Jun-Ichi

× Saitoh, Jun-Ichi

WEKO 485535

Saitoh, Jun-Ichi

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Nakano, Takashi

× Nakano, Takashi

WEKO 485536

Nakano, Takashi

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大野 達也

× 大野 達也

WEKO 485537

en 大野 達也

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小此木 範之

× 小此木 範之

WEKO 485538

en 小此木 範之

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渋谷 圭

× 渋谷 圭

WEKO 485539

en 渋谷 圭

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清原 浩樹

× 清原 浩樹

WEKO 485540

en 清原 浩樹

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若月 優

× 若月 優

WEKO 485541

en 若月 優

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中野 隆史

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WEKO 485542

en 中野 隆史

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抄録
内容記述タイプ Abstract
内容記述 Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography-based brachytherapy. Eighty patients with Stage IB1-IVA cervical cancer, who had undergone treatment with combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 and May 2011, were retrospectively analyzed. External beam radiotherapy (50 Gy) with central shielding after 20-40 Gy was performed for each patient. Cisplatin-based chemotherapy was administered concurrently to advanced-stage patients aged ≤75 years. Brachytherapy was delivered in four fractions of 6 Gy per week. In-room computed tomography imaging with applicator insertion was performed for treatment planning. Information from physical examinations at diagnosis, and brachytherapy and magnetic resonance imaging at diagnosis and just before the first brachytherapy session, were referred to for contouring of the high-risk clinical target volume. The median follow-up duration was 60 months. The 5-year local control, pelvic progression-free survival and overall survival rates were 94%, 90% and 86%, respectively. No significant differences in 5-year local control rates were observed between Stage I, Stage II and Stage III-IVA patients. Conversely, a significant difference in the 5-year overall survival rate was observed between Stage II and III-IVA patients (97% vs 72%; P = 0.006). One patient developed Grade 3 late bladder toxicity. No other Grade 3 or higher late toxicities were reported in the rectum or bladder. In conclusion, excellent local control rates were achieved with minimal late toxicities in the rectum or bladder, irrespective of clinical stage.
書誌情報 Journal of radiation research

巻 58, 号 4, p. 543-551, 発行日 2016-12
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 1349-9157
PubMed番号
識別子タイプ PMID
関連識別子 27986859
DOI
識別子タイプ DOI
関連識別子 10.1093/jrr/rrw121
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