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Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform
https://repo.qst.go.jp/records/48309
https://repo.qst.go.jp/records/4830958e57d42-e9ba-42ef-b172-62a4c4ab0153
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-21 | |||||
| タイトル | ||||||
| タイトル | Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kim, Jeong-Hwan
× Kim, Jeong-Hwan× Eguchi, Haruki× Umemura, Masanari× Itaru, Sato× Yamada, Shigeki× Yujiro, Hoshino× Masuda, Takatsugu× Ichio, Aoki× Sakurai, Kazuo× Yamamoto, Masahiro× Yoshihiro, Ishikawa× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nanoparticulate agents for magnetic drug delivery systems (DDSs) have extensive applications in targeted drug delivery, contrast imaging and therapeutics. However, no simple synthetic method for magnetic DDS agents has been developed without the need to add magnetic nanoparticles. Here, we describe the one-step fabrication of ‘all-in-one’ magneto-assemblies using an ‘inorganic-metal-salt-free’ method, involving spontaneous self-assembly of the water-insoluble prodrug μ-oxo-bis(N,N′-ethylenebis(salicylideniminato)iron) [Fe(salen)] (magnetic core) with polypyrrole (PPy)-b-polycaprolactone (PCL) smart diblock copolymers. In the system, PCL serves as a heat-responsive core scaffold, and PPy serves as an electronic core-size controller and pH-responsive shell. This core–shell nanocomposite has a high-loading capacity (~90%), and the core size is tunable by incorporating albumin or gum arabic as bio-coating agents, which also provide colloidal stability, biocompatibility and thermo-stability. Fe(salen), which has intrinsic antitumor activity, also has ubiquitous magnetic properties, which are dramatically enhanced in these molecular assemblies with magnetic coupling. Moreover, these multifunctional nanoassemblies can be delivered magnetically, can serve as magnetic resonance imaging contrast agents, can generate magneto-hyperthermal effects and can enable magnetic field-triggered release of Fe(salen) molecules under acidic conditions. | |||||
| 書誌情報 |
NPG asia materials 巻 9, p. e367, 発行日 2017-03 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/am.2017.29 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/am/journal/v9/n3/full/am201729a.html | |||||
| 関連名称 | https://www.nature.com/am/journal/v9/n3/full/am201729a.html | |||||
