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Monoglucosyl-rutin as a potential radioprotector in mammalian cells.
https://repo.qst.go.jp/records/48216
https://repo.qst.go.jp/records/482163e9b40f9-c9f5-4965-b698-167924a1250e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-26 | |||||
| タイトル | ||||||
| タイトル | Monoglucosyl-rutin as a potential radioprotector in mammalian cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sunada, Shigeaki
× Sunada, Shigeaki× Fujisawa, Hiroshi× M, Cartwright Ian× Maeda, Junko× A, Brents Colleen× Mizuno, Kazue× Aizawa, Yasushi× A, Kato Takamitsu× Uesaka, Mitsuru× 砂田 成章× 藤澤 寛× 相澤 恭× 上坂 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study, the role of monoglucosyl‑rutin as a potential radioprotector was investigated using mammalian cell culture models. Cell survival and DNA damage were assessed using colony formation, sister chromatid exchange and γH2AX assays. It was demonstrated that monoglucosyl‑rutin was able to increase cell survival when exposed to ionizing radiation, possibly by decreasing the amount of base damage experienced by the cell. However, the present study also demonstrated that, despite monoglucosyl‑rutin exhibiting radioprotective effects at low doses, high doses of monoglucosyl‑rutin led to a decrease in plating efficiency and an increased doubling time. This effect may be due to double‑strand breaks caused by high concentrations of monoglucosyl‑rutin. | |||||
| 書誌情報 |
Molecular medicine reports 巻 10, 号 1, p. 10-14, 発行日 2014-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1791-2997 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24788331 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/mmr.2014.2181 | |||||
