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RBE study using solid state microdosimetry in heavy ion therapy
https://repo.qst.go.jp/records/48207
https://repo.qst.go.jp/records/482070064fa09-e7dd-4847-8d7c-478f8ba1ccd2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-25 | |||||
| タイトル | ||||||
| タイトル | RBE study using solid state microdosimetry in heavy ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
ＢＯＬＳＴ, Ｄａｖｉｄ
× ＢＯＬＳＴ, Ｄａｖｉｄ× Ｔｒａｎ, Ｔｈｕｙ Ｌｉｎｈ× Ｃｈａｒｔｉｅｒ, Ｌａｃｈｌａｎ× Ｐｒｏｋｏｐｏｖｉｃｈ, Ａｎｔｈｏｎｙ× Pogossov, Alex× Guatelli, Susanna× Reinhard, Mark× Ｐｅｔａｓｅｃｃａ, Ｍａｒｃｏ× Lerch, Michael× 松藤, 成弘× Perevertaylo, Vladimir× Fleta, Celeste× Rosenfeld, Anatoly× Jackson, Michael× Pellegrini, Giulio× ＢＯＬＳＴ Ｄａｖｉｄ× Ｔｒａｎ Ｔｈｕｙ Ｌｉｎｈ× Ｃｈａｒｔｉｅｒ Ｌａｃｈｌａｎ× Ｐｒｏｋｏｐｏｖｉｃｈ Ａｎｔｈｏｎｙ× Ｐｅｔａｓｅｃｃａ Ｍａｒｃｏ× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The response of two types of 10 mm thick silicon-on-insulator (SOI) detectors in a 12C ion therapy beam with extremely high spatial resolution are presented in this work. The two detectors used are the “bridge” microdosimeter with isolated 3D sensitive volumes (SVs) and the ultra-thin 3D (U3DTHIN) detector with nþ and pþ 3D columnar structures. Both detectors were investigated at various depths in a water phantom along the central axis of the spread-out Brag peak (SOBP) of a 290 MeV/u 12C ion beam at the Heavy Ion Medical Accelerator in Chiba, Japan. Based on the Microdosimetric Kinetic (MK) model and the microdosimetric quantities measured with the two detectors, the relative biological effectiveness (RBE) values were derived and compared to results obtained with the tissue-equivalent proportional counter (TEPC). Derived RBE10 values obtained with the U3DTHIN detector were considerably higher than those obtained with the bridge microdosimeter and the TEPC along the SOBP. Due to the high spatial resolution of the microdosimeters, more detailed measurements were obtained at the end of the SOBP compared to the TEPC. The maximum derived RBE10 found using the U3DTHIN detector and bridge microdosimeter were approximately 2.66 and 2.58, respectively which are higher than the RBE10 value of 2.35 obtained with the TEPC due to the lack of high spatial resolution in the TEPC. The discrepancy in the results obtained using the two detectors is due to the difference in geometry of the SVs in the two detectors. This work presents an application of different types of SOI micodosimeters in a 12C ion therapy beam and has demonstrated that the microdosimeter with micron sized 3D SVs is more desirable for accurate lineal energy measurement and RBE determination. Silicon microdosimetry has demonstrated a simple, fast and accurate method for routine Quality Assurance in charged particle therapy. |
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| 書誌情報 |
Radiation Measurements 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radmeas.2017.02.008 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.radmeas.2017.02.008 | |||||
| 関連名称 | http://dx.doi.org/10.1016/j.radmeas.2017.02.008 | |||||
