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p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
https://repo.qst.go.jp/records/48161
https://repo.qst.go.jp/records/48161b3c87bfd-c86d-4fa9-9712-486b174abd75
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-24 | |||||
| タイトル | ||||||
| タイトル | p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Jeannot, Pauline
× Jeannot, Pauline× Nowosad, Ada× T, Perchey Renaud× Callot, Caroline× Bennana, Evangeline× 勝部, 孝則× Mayeux, Patrick× Guillonneau, François× Manenti, Stéphane× Besson, Arnaud× 勝部 孝則 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | p27Kip1 (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metastasis, in part by promoting epithelial to mesenchymal transition. Herein, we find that p27 promotes cell invasion by binding to and regulating the activity of Cortactin, a critical regulator of invadopodia formation. p27 localizes to invadopodia and limits their number and activity. p27 promotes the interaction of Cortactin with PAK1. In turn, PAK1 promotes invadopodia turnover by phosphorylating Cortactin, and expression of Cortactin mutants for PAK-targeted sites abolishes p27's effect on invadopodia dynamics. Thus, in absence of p27, cells exhibit increased invadopodia stability due to impaired PAK1-Cortactin interaction, but their invasive capacity is reduced compared to wild-type cells. Overall, we find that p27 directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1/Cortactin pathway. | |||||
| 書誌情報 |
eLife 巻 6, p. e22207, 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | ELIFE SCIENCES PUBLICATIONS LTD | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2050-084X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.7554/eLife.22207 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.7554/eLife.22207 | |||||
| 関連名称 | http://dx.doi.org/10.7554/eLife.22207 | |||||
