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  1. 原著論文

A multi-stage carcinogenesis model to investigate calorie restriction as a potential tool for post-irradiation mitigation of cancer risk

https://repo.qst.go.jp/records/48096
https://repo.qst.go.jp/records/48096
0dcba235-bdc3-45b5-a13c-ebc1733e688f
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-07-19
タイトル
タイトル A multi-stage carcinogenesis model to investigate calorie restriction as a potential tool for post-irradiation mitigation of cancer risk
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 谷, 修祐

× 谷, 修祐

WEKO 482959

谷, 修祐

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Blyth, Benjamin

× Blyth, Benjamin

WEKO 482960

Blyth, Benjamin

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尚, 奕

× 尚, 奕

WEKO 482961

尚, 奕

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森岡, 孝満

× 森岡, 孝満

WEKO 482962

森岡, 孝満

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柿沼, 志津子

× 柿沼, 志津子

WEKO 482963

柿沼, 志津子

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島田, 義也

× 島田, 義也

WEKO 482964

島田, 義也

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谷 修祐

× 谷 修祐

WEKO 482965

en 谷 修祐

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Blyth Benjamin

× Blyth Benjamin

WEKO 482966

en Blyth Benjamin

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尚 奕

× 尚 奕

WEKO 482967

en 尚 奕

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森岡 孝満

× 森岡 孝満

WEKO 482968

en 森岡 孝満

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柿沼 志津子

× 柿沼 志津子

WEKO 482969

en 柿沼 志津子

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島田 義也

× 島田 義也

WEKO 482970

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 Ongoing uncertainty regarding the risk of radiation-induced cancer after low dose exposures adds to anxiety in exposed populations, particularly following accidental exposures where informed consent was not obtained. Safe, effective and simple lifestyle changes which can be proven to help mitigate or offset radiation-induced excess cancer risk might provide individuals exposed to radiation the opportunity to pro-actively reduce their cancer risk, while such empowerment could also improve mental health and well-being. Here, we applied a multi-stage carcinogenesis mathematical model to mouse lifespan and cancer data for an intervention using adult-onset calorie restriction following irradiation in early life. We re-evaluated autopsy records with the assistance of a veterinary pathologist to determine which tumours were the probable cause of death in order to calculate age-specific mortality. The model revealed that in both irradiated and unirradiated mice, calorie restriction reduced the age-specific mortality of all solid tumours and hepatocellular carcinoma across most of the lifespan, with the mortality rate more dependent on age due to an increase in the number of ‘steps’. Conversely, irradiation did not significantly alter the number of steps, but did increase the overall transition rate between the steps. We show that the extent of the protective effect of calorie restriction is independent of the cancer induction from the radiation exposure, and discuss future avenues of research to explore the utility of calorie restriction as an example of a potential post-irradiation mitigation strategy.
書誌情報 Journal of Cancer Prevention

巻 21, 号 2, p. 115-120, 発行日 2016-01
出版者
出版者 Korean Society of Cancer Prevention
ISSN
収録物識別子タイプ ISSN
収録物識別子 2288-3657
DOI
識別子タイプ DOI
関連識別子 10.15430/JCP.2016.21.2.115
関連サイト
識別子タイプ URI
関連識別子 http://www.jcpjournal.org/journal/view.html?doi=10.15430/JCP.2016.21.2.115
関連名称 http://www.jcpjournal.org/journal/view.html?doi=10.15430/JCP.2016.21.2.115
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