WEKO3
アイテム
Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway
https://repo.qst.go.jp/records/48091
https://repo.qst.go.jp/records/4809198635c06-bbad-4584-9d9c-da0716ac3a97
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-13 | |||||
| タイトル | ||||||
| タイトル | Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Su, Fengtao
× Su, Fengtao× Bhattacharya, Souparno× Abdisalaam, Salim× Mukherjee, Shibani× 矢島, 浩彦× Yang, Yanyong× Mishra, Ritu× Srinivasan, Kalayarasan× Ghose, Subroto× J., Chen David× M., Yannone Steven× Asaithamby, Aroumougame× 矢島 浩彦 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Faithful and complete genome replication in human cells is essential for preventing the accumulation of cancer-promoting mutations. WRN, the protein defective in Werner syndrome, plays critical roles in preventing replication stress, chromosome instability, and tumorigenesis. Herein, we report that ATR-mediated WRN phosphorylation is needed for DNA replication and repair upon replication stress. A serine residue, S1141, in WRN is phosphorylated in vivo by the ATR kinase in response to replication stress. ATR-mediated WRN S1141 phosphorylation leads to ubiquitination of WRN, facilitating the reversible interaction of WRN with perturbed replication forks and subsequent degradation of WRN. The dynamic interaction between WRN and DNA is required for the suppression of new origin firing and Rad51-dependent double-stranded DNA break repair. Significantly, ATR-mediated WRN phosphorylation is critical for the suppression of chromosome breakage during replication stress. These findings reveal a unique role for WRN as a modulator of DNA repair, replication, and recombination, and link ATR-WRN signaling to the maintenance of genome stability. | |||||
| 書誌情報 |
Oncotarget 巻 7, 号 1, p. 46-65, 発行日 2016-01 |
|||||
| 出版者 | ||||||
| 出版者 | Inpact Journals | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.18632/oncotarget.6659 | |||||
