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Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3
https://repo.qst.go.jp/records/47888
https://repo.qst.go.jp/records/47888f1bed5e7-be93-4758-b510-f399b8122ded
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-27 | |||||
| タイトル | ||||||
| タイトル | Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakumu, Erina
× Kakumu, Erina× Nakanishi, Seiya× M., Shiratori Hiromi× Kato, Akari× Kobayashi, Wataru× Machida, Shinichi× Yasuda, Takeshi× Adachi, Naoko× Saito, Naoaki× Ikura, Tsuyoshi× Kurumizaka, Hitoshi× Kimura, Hiroshi× Yokoi, Masayuki× Sakai, Wataru× Sugasawa, Kaoru× 安田 武嗣 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the mammalian global genome nucleotide excision repair pathway, two damage recognition factors, XPC and UV-DDB, play pivotal roles in the initiation of the repair reaction. However, the molecular mechanisms underlying regulation of the lesion recognition process in the context of chromatin structures remain to be understood. Here, we show evidence that damage recognition factors tend to associate with chromatin regions devoid of certain types of acetylated histones. Treatment of cells with histone deacetylase inhibitors retarded recruitment of XPC to sites of UV-induced DNA damage and the subsequent repair process. Biochemical studies showed novel multifaceted interactions of XPC with histone H3, which were profoundly impaired by deletion of the N-terminal tail of histone H3. In addition, histone H1 also interacted with XPC. Importantly, acetylation of histone H3 markedly attenuated the interaction with XPC in vitro, and local UV irradiation of cells decreased the level of H3K27ac in the damaged areas. Our results suggest that histone deacetylation plays a significant role in the process of DNA damage recognition for nucleotide excision repair and that the localization and functions of XPC can be regulated by acetylated states of histones. | |||||
| 書誌情報 |
Genes to Cells 巻 22, 号 3, p. 310-327, 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | Wiley-Japan | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/gtc.12479 | |||||
