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  1. 原著論文

Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis

https://repo.qst.go.jp/records/47789
https://repo.qst.go.jp/records/47789
e0c58dbd-20ba-4bea-a916-79697a8c1dac
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-26
タイトル
タイトル Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Ito, Hiroshi

× Ito, Hiroshi

WEKO 479699

Ito, Hiroshi

Search repository
Ikoma, Yoko

× Ikoma, Yoko

WEKO 479700

Ikoma, Yoko

Search repository
Seki, Chie

× Seki, Chie

WEKO 479701

Seki, Chie

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Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 479702

Kimura, Yasuyuki

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Kawaguchi, Hiroshi

× Kawaguchi, Hiroshi

WEKO 479703

Kawaguchi, Hiroshi

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Takuwa, Hiroyuki

× Takuwa, Hiroyuki

WEKO 479704

Takuwa, Hiroyuki

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Ichise, Masanori

× Ichise, Masanori

WEKO 479705

Ichise, Masanori

Search repository
Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 479706

Suhara, Tetsuya

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Kanno, Iwao

× Kanno, Iwao

WEKO 479707

Kanno, Iwao

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伊藤 浩

× 伊藤 浩

WEKO 479708

en 伊藤 浩

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生駒 洋子

× 生駒 洋子

WEKO 479709

en 生駒 洋子

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関 千江

× 関 千江

WEKO 479710

en 関 千江

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木村 泰之

× 木村 泰之

WEKO 479711

en 木村 泰之

Search repository
川口 拓之

× 川口 拓之

WEKO 479712

en 川口 拓之

Search repository
田桑 弘之

× 田桑 弘之

WEKO 479713

en 田桑 弘之

Search repository
市瀬 正則

× 市瀬 正則

WEKO 479714

en 市瀬 正則

Search repository
須原 哲也

× 須原 哲也

WEKO 479715

en 須原 哲也

Search repository
菅野 巖

× 菅野 巖

WEKO 479716

en 菅野 巖

Search repository
抄録
内容記述タイプ Abstract
内容記述 Objectives: In PET studies for neuroreceptors, tracer kinetics are described by the two-tissue compartment model (2-TCM), and binding parameters including the total distribution volume (VT), nondisplaceable distribution volume (VND), and binding potential (BPND) can be determined from model parameters estimated by kinetic analysis. The stability of binding parameter estimates depends on the kinetic characteristics of radioligands. To describe these kinetic characteristics, we previously developed a Two-phase graphic plot analysis in which VND and VT can be estimated from the x-intercept of regression lines for early and delayed phase, respectively. In this study, we applied this graphic plot analysis to visual evaluation of the kinetic characteristics of radioligands for neuroreceptors, and investigated a relationship between the shape of these graphic plots and the stability of binding parameters estimated by the kinetic analysis with 2-TCM in simulated brain tissue time-activity curves (TACs) with various binding parameters.
Methods: 90-min TACs were generated with the arterial input function and assumed kinetic parameters according to 2-TCM. Graphic plot analysis was applied to these simulated TACs, and the curvature of the plot for each TAC was evaluated visually. TACs with several noise levels were also generated with various kinetic parameters, and the bias and variation of binding parameters estimated by kinetic analysis was calculated in each TAC. These bias and variation were compared with the shape of graphic plots.
Results: The graphic plots showed larger curvature for TACs with higher specific binding and slower dissociation of specific binding. The quartile deviations of VND and BPND determined by kinetic analysis were smaller for radioligands with slow dissociation.
Conclusions: The larger curvature of graphic plots for radioligands with slow dissociation might indicate a stable determination of VND and BPND by kinetic analysis. For investigation of the kinetics of radioligands, such kinetic characteristics should be considered.
書誌情報 Annals of Nuclear Medicine

巻 31, 号 4, p. 273-282, 発行日 2017-02
出版者
出版者 Springer
PubMed番号
識別子タイプ PMID
関連識別子 28181119
DOI
識別子タイプ DOI
関連識別子 10.1007/s12149-017-1155-6
関連サイト
識別子タイプ URI
関連識別子 http://link.springer.com/article/10.1007/s12149-017-1155-6
関連名称 http://link.springer.com/article/10.1007/s12149-017-1155-6
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