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Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis
https://repo.qst.go.jp/records/47789
https://repo.qst.go.jp/records/47789e0c58dbd-20ba-4bea-a916-79697a8c1dac
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-26 | |||||
| タイトル | ||||||
| タイトル | Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Ikoma, Yoko× Seki, Chie× Kimura, Yasuyuki× Kawaguchi, Hiroshi× Takuwa, Hiroyuki× Ichise, Masanori× Suhara, Tetsuya× Kanno, Iwao× 伊藤 浩× 生駒 洋子× 関 千江× 木村 泰之× 川口 拓之× 田桑 弘之× 市瀬 正則× 須原 哲也× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: In PET studies for neuroreceptors, tracer kinetics are described by the two-tissue compartment model (2-TCM), and binding parameters including the total distribution volume (VT), nondisplaceable distribution volume (VND), and binding potential (BPND) can be determined from model parameters estimated by kinetic analysis. The stability of binding parameter estimates depends on the kinetic characteristics of radioligands. To describe these kinetic characteristics, we previously developed a Two-phase graphic plot analysis in which VND and VT can be estimated from the x-intercept of regression lines for early and delayed phase, respectively. In this study, we applied this graphic plot analysis to visual evaluation of the kinetic characteristics of radioligands for neuroreceptors, and investigated a relationship between the shape of these graphic plots and the stability of binding parameters estimated by the kinetic analysis with 2-TCM in simulated brain tissue time-activity curves (TACs) with various binding parameters. Methods: 90-min TACs were generated with the arterial input function and assumed kinetic parameters according to 2-TCM. Graphic plot analysis was applied to these simulated TACs, and the curvature of the plot for each TAC was evaluated visually. TACs with several noise levels were also generated with various kinetic parameters, and the bias and variation of binding parameters estimated by kinetic analysis was calculated in each TAC. These bias and variation were compared with the shape of graphic plots. Results: The graphic plots showed larger curvature for TACs with higher specific binding and slower dissociation of specific binding. The quartile deviations of VND and BPND determined by kinetic analysis were smaller for radioligands with slow dissociation. Conclusions: The larger curvature of graphic plots for radioligands with slow dissociation might indicate a stable determination of VND and BPND by kinetic analysis. For investigation of the kinetics of radioligands, such kinetic characteristics should be considered. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 31, 号 4, p. 273-282, 発行日 2017-02 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28181119 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-017-1155-6 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://link.springer.com/article/10.1007/s12149-017-1155-6 | |||||
| 関連名称 | http://link.springer.com/article/10.1007/s12149-017-1155-6 | |||||
