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Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments
https://repo.qst.go.jp/records/47766
https://repo.qst.go.jp/records/47766a6e351b8-2dec-4c33-b6de-ad5e798e1e49
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-07-26 | |||||
| タイトル | ||||||
| タイトル | Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kanamitsu, Kayoko
× Kanamitsu, Kayoko× Arakawa, Ryosuke× Sugiyama, Yuichi× Suhara, Tetsuya× Kusuhara, Hiroyuki× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of drugs in the central nervous system (CNS) is closely related to occupancy of their target receptor. In this study, we integrated plasma concentrations, in vitro/in vivo data for receptor or protein binding, and in silico data, using a physiologically based pharmacokinetic model, to examine the predictability of receptor occupancy in humans. The occupancy of the dopamine D2 receptor and the plasma concentrations of the antipsychotic drugs quetiapine and perospirone in humans were collected from the literature or produced experimentally. Association and dissociation rate constants and unbound fractions in the serum and brain were determined in vitro/in vivo using human D2 receptor-expressing membrane fractions, human serum and mouse brain. The permeability of drugs across the blood–brain barrier was estimated based on their physicochemical properties. The effect of a metabolite of perospirone, ID-15036, was also considered. The time profiles of D2 receptor occupancy following oral dose of quetiapine and perospirone predicted were similar to the observed values. This approach could assist in the design of clinical studies for drug development and the prediction of the impact of drug–drug interactions on CNS function in clinical settings. | |||||
| 書誌情報 |
Drug Metabolism and Pharmacokinetics 巻 31, 号 6, p. 395-404, 発行日 2016-07 |
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| 出版者 | ||||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-4367 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 27745731 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.dmpk.2016.07.003 | |||||
