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Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model.
https://repo.qst.go.jp/records/47760
https://repo.qst.go.jp/records/4776039a1bc23-6ff5-4174-be2d-d0e512fc6461
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-25 | |||||
| タイトル | ||||||
| タイトル | Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishino, Asuka
× Nishino, Asuka× Tajima, Yosuke× Takuwa, Hiroyuki× Masamoto, Kazuto× Taniguchi, Junko× Wakizaka, Hidekatsu× Kokuryo, Daisuke× Urushihata, Takuya× Aoki, Ichio× Kanno, Iwao× Tomita, Yutaka× Suzuki, Norihiro× Ikoma, Yoko× Ito, Hiroshi× 西野 明日香× 田桑 弘之× 脇坂 秀克× 漆畑 拓弥× 青木 伊知男× 生駒 洋子× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated the chronic effects of cerebral hypoperfusion on neuronal density and functional hyperemia using our misery perfusion mouse model under unilateral common carotid artery occlusion (UCCAO). Neuronal density evaluated 28 days after UCCAO using [(11)C]flumazenil-PET and histology indicated no neurologic deficit in the hippocampus and neocortex. CBF response to sensory stimulation was assessed using laser-Doppler flowmetry. Percentage changes in CBF response of the ipsilateral hemisphere to UCCAO were 18.4 ± 3.0%, 6.9 ± 2.8%, 6.8 ± 2.3% and 4.9 ± 2.4% before, and 7, 14 and 28 days after UCCAO, respectively. Statistical significance was found at 7, 14 and 28 days after UCCAO (P < 0.01). Contrary to our previous finding (Tajima et al. 2014) showing recovered CBF response to hypercapnia on 28 days after UCCAO using the same model, functional hyperemia was sustained and became worse 28 days after UCCAO. | |||||
| 書誌情報 |
Scientific Reports 巻 6, p. 25072-1-25072-8, 発行日 2016-04 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 27116932 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep25072 | |||||
