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Amino acid transport system - A substrate predicts the therapeutic effects of particle radiotherapy
https://repo.qst.go.jp/records/47715
https://repo.qst.go.jp/records/477153680c9b2-7af9-40d5-a533-57abfe431494
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-19 | |||||
| タイトル | ||||||
| タイトル | Amino acid transport system - A substrate predicts the therapeutic effects of particle radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tomoya, Uehara
× Tomoya, Uehara× Mariko, Watanabe× Hiroyuki, Suzuki× Furusawa, Yoshiya× Yasushi, Arano× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract: L-[methyl-11C]Methionine (11C-Met) is useful for estimating the therapeutic efficiencies of conventional radiotherapy and carbon-ion radiotherapy. Due to the short half-life of 11C, the development of other radionuclide-labeled probes, particularly those that afford similar diagnostic information to 11C-Met, is being sought. Since the energy-dependent cellular functions involved in 11C-Met reflect radiotherapeutic effects, we herein evaluated the activity of energy-dependent amino acid transport system A in order to estimate radiotherapeutic effects using the specific system A substrate, alpha-[1-14C]-methyl-aminoisobutyric acid (14C-MeAIB) because 18F- or 123I-labeled probes for system A have already been produced. Methods: A carbon-ion beam was used as the radiation source. Cellular growth and the accumulation of 14C-MeAIB or L-[14C-methyl]methionine (14C-Met) were evaluated over time in in vitro cultured human salivary gland (HSG) tumor cells (3 Gy) or in vivo murine xenografts of HSG tumors (6 or 25 Gy) before and after irradiation with the carbon-ion beam. Results: In an in vitro study, after 3-Gy irradiation dose, the uptakes of 14C-Met and 14C-MeAIB decreased over a 5-day period. In xenografts of HSG in mice, in vivo tumor re-growth was observed on day 10 after the 6-Gy irradiation dose, but was not detected after the 25-Gy irradiation dose. Consistent with these results, no significant differences were noted in the in vivo tumor uptake of 14C-MeAIB before and after the 6-Gy irradiation dose, whereas a significant decrease was observed after the 25-Gy irradiation dose. Conclusions: The results of the present study indicate that the activity of system A reflects the therapeutic efficacy of carbon-ion radiotherapy as well as 14C-Met. Therefore, 18F- or 123I-labeled probes for system A have potential as widely usable probes to evaluate the effects of tumor radiotherapy. | |||||
| 書誌情報 |
PLOS ONE 巻 12, 号 2, p. e0173096-1-e0173096-13, 発行日 2017-02 |
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| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1932-6203 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28245294 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1371/journal.pone.0173096 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1371/journal.pone.0173096 | |||||
| 関連名称 | http://dx.doi.org/10.1371/journal.pone.0173096 | |||||
