WEKO3
アイテム
Sensitive detection of radiation-induced medulloblastomas after acute or protracted gamma ray exposures in Ptch1 heterozygous mice using a radiation-specific molecular signature.
https://repo.qst.go.jp/records/47699
https://repo.qst.go.jp/records/47699bfd45ee3-c59c-4a95-99fb-83093c69110e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-30 | |||||
| タイトル | ||||||
| タイトル | Sensitive detection of radiation-induced medulloblastomas after acute or protracted gamma ray exposures in Ptch1 heterozygous mice using a radiation-specific molecular signature. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鶴岡, 千鶴
× 鶴岡, 千鶴× Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ× 森岡, 孝満× 上西, 睦美× 品川, まゆみ× 島田, 義也× 柿沼, 志津子× 鶴岡 千鶴× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 森岡 孝満× 上西 睦美× 品川 まゆみ× 島田 義也× 柿沼 志津子 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently reported studies have led to a heightened awareness of the risks of cancer induced by diagnostic radiological imaging, and in particular, the risk of brain cancer after childhood CT scans. One feature of Ptch1+/– mice is their sensitivity to radiation-induced medulloblastomas (an embryonic cerebellar tumor) during a narrow window of time centered on the days around birth. Little is known about the dynamics of how dose protraction interacts with such narrow windows of sensitivity in individual tissues. Using medulloblastomas from irradiated Ptch1+/– mice with a hybrid C3H 3 C57BL/6 F1 genetic background, we previ- ously showed that the alleles retained on chromosome 13 (which harbors the Ptch1 gene) reveal two major mechanisms of loss of the wild-type allele. The loss of parental alleles from the telomere extending up to or past the Ptch1 locus by recombination (spontaneous type) accounts for almost all medulloblastomas in nonirradiated mice, while tumors in irradiated mice often exhibited interstitial deletions, which start downstream of the wild-type Ptch1 and extend up varying lengths towards the centromere (radiation type). In this study, Ptch1+/– mice were exposed to an acute dose of either 100 or 500 mGy gamma rays in utero or postnatally, or the same radiation doses protracted over a four-day period, and were monitored for medulloblastoma development. The results showed dose- and age-dependent radiation-induced type tumors. Furthermore, the size of the radiation-induced deletion differed with the dose rate. The results of this work suggest that tumor latency may be related to the size of the deletion. In this study, 500 mGy exposure produced radiation-induced type tumors at all ages and dose rates, while 100 mGy exposure did not significantly produce radiation-induced type tumors. The radiation signature allows for unique mechanistic insight into the action of radiation to induce DNA lesions with known causal relation- ship to a specific tumor type, particularly for doses and dose rates that are relevant to both diagnostic and accidental radiological exposures. | |||||
| 書誌情報 |
Radiation Research 巻 186, 号 4, p. 407-414, 発行日 2016-12 |
|||||
| 出版者 | ||||||
| 出版者 | Radiation Research Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1938-5404 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RR14499.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.bioone.org/doi/abs/10.1667/RR14478.1 | |||||
| 関連名称 | http://www.bioone.org/doi/abs/10.1667/RR14478.1 | |||||
