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Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
https://repo.qst.go.jp/records/47696
https://repo.qst.go.jp/records/4769683ca3ca1-82a1-4775-8678-65a6cfd0df42
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-27 | |||||
| タイトル | ||||||
| タイトル | Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukumura, Toshimitsu
× Fukumura, Toshimitsu× Okada, Kazuhiro× Ferenc, Szelecsenyi× Kovacs, Zoltan× Suzuki, Kazutoshi× 福村 利光× Ｆｅｒｅｎｃ Ｓｚｅｌｅｃｓｅｎｙｉ× ゾルタン コバックス× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Copper-61 (T-1/2 = 3.41 h) produced via the Co-59(alpha, 2n)Cu-61 nuclear reaction using natural Co target was isolated from the irradiated target by two methods developed here and applied for preparation of (Cu-61-ATSM) (Cu-61-diacetyl-bis(N-4-methylthiosemicarbazone)), known as an imaging agent of hypoxic tissue. A commercially available cobalt disk (thickness: 125 mum) was irradiated with 40 MeV (37.9 MeV on target) a particles, then treated with conc. HNO3, and the Cu-61 was separated by two different methods, i.e. a two column method using a cation and an anion exchange column; and a one Column method using a column packed with chelating resin, Chelex 100. Both separation methods gave satisfactory results, though the latter method was superior because of the simplicity of the apparatus, the separation procedure and somewhat shorter processing time. Around 1.1 GBq of 61Cu(2+) were obtained with >95% yield (decay corrected) from Co target at 10 I-LA for 1 h irradiation, and with the radionuclidic purity of >98% (EOS). The only radionuclidic impurity in the isolated Cu-61(2+) solution was identified to be Cu-60 at EOS but no radionuclidic impurity was observed after 50 hours. The solution of Cu-61-ATSM was prepared in >85% radiochemical yield with >95% radiochemical purity. \nDo you want to read the rest of this article? Request full-text \nPractical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61CU-ATSM. Available from: https://www.researchgate.net/publication/244745391_Practical_production_of_61Cu_using_natural_Co_target_and_its_simple_purification_with_a_chelating_resin_for_61CU-ATSM [accessed Mar 27, 2017]. |
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| 書誌情報 |
Radiochimica Acta 巻 92, p. 209-214, 発行日 2004-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-8230 | |||||
