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Synthesis and biodistribution of 34mCl-labeled 2-chloro-2-deoxy-D-glucose:A major impurity in[18F]FDG injection
https://repo.qst.go.jp/records/47694
https://repo.qst.go.jp/records/476946571f2da-57bb-479f-8053-6e6cff95a3cd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-27 | |||||
| タイトル | ||||||
| タイトル | Synthesis and biodistribution of 34mCl-labeled 2-chloro-2-deoxy-D-glucose:A major impurity in[18F]FDG injection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukumura, Toshimitsu
× Fukumura, Toshimitsu× Takei, Makoto× Suzuki, Kazutoshi× 福村 利光× 武井 誠× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | No-carrier-added 2-[(34m)Cl]chloro-2-deoxy-d-glucose ([(34m)Cl]ClDG) was prepared via nucleophilic displacement reaction of 1, 3, 4, 6-tetra-O-acetyl-2-trifluoromethansulfonyl mannose with K[(34m)Cl]Cl/kryptofix 222 complex using (34m)Cl(-) produced via the (nat)S(alpha, 2n) nuclear reactions. The synthesis time from enrichment of [(34m)Cl]Cl(-) was approximately 45min and the radiochemical yield was 79.6+/-6.7% (n=3) with decay correction. Animal PET studies showed that the behavior of [(34m)Cl]ClDG was quite different from that of [(18)F]FDG. [(34m)Cl]ClDG did not accumulate in any organ and was excreted as [(34m)Cl]ClDG. | |||||
| 書誌情報 |
Applied Radiation and Isotopes 巻 66, 号 12, p. 1905-1909, 発行日 2008-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
