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Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer
https://repo.qst.go.jp/records/47676
https://repo.qst.go.jp/records/47676efd5c8eb-6c46-4270-a5aa-edd95fc475cd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-22 | |||||
| タイトル | ||||||
| タイトル | Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukahori, Mai
× Fukahori, Mai× Matsufuji, Naruhiro× Himukai, Takeshi× Kanematsu, Nobuyuki× Mizuno, Hideyuki× Fukumura, Akifumi× Tsuji, Hiroshi× Kamada, Tadashi× 深堀 麻衣× 松藤 成弘× 日向 猛× 兼松 伸幸× 水野 秀之× 福村 明史× 辻 比呂志× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The aim of this study was to estimate normal tissue complication probability (NTCP) parameters for late rectal complications after carbon ion radiotherapy (C-ion RT) for prostate cancer. Methods and materials: A total of 163 patients were used to derive NTCP parameters. These patients were treated with relative biological effectiveness (RBE)-weighted dose ranging from 57.6 Gy (RBE) up to 72 Gy (RBE) and included in dose escalation trials. The Lyman–Kutcher–Burman (LKB) model was used and the model parameters were fit to the relation between dose and complication observed after C-ion RT. Results: The resulting NTCP parameters were the volume effect parameter; n = 0.035 (95% CI: 0.024– 0.047), the steepness of the NTCP curve; m = 0.10 (0.084–0.13), the tolerance dose associated with 50% probability of complication; TD50 = 63.6 Gy (RBE) (61.8–65.4 Gy (RBE)) for GradeP1, n = 0.012 (0.0050–0.023), m = 0.046 (0.033–0.062), TD50 = 69.1 Gy (RBE) (67.6–70.9 Gy (RBE)) for GradeP2. Conclusion: A new set of rectal NTCP parameters in C-ion RT was determined. The rather small n values suggest that the rectum was consistent with being strictly serial organ. The new derived parameter values facilitate estimation of rectal NTCP in C-ion RT. |
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| 書誌情報 |
Radiotherapy and Oncology 巻 118, 号 1, p. 136-140, 発行日 2016-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier BV | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26700600 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radonc.2015.11.023 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S016781401500643X | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S016781401500643X | |||||
