WEKO3
アイテム
Imaging the role of TLR4 on cell proliferation and inflammation after cerebral ischemia by PET
https://repo.qst.go.jp/records/47653
https://repo.qst.go.jp/records/476531183d37c-eb59-4fda-a243-38cbc30beece
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-09 | |||||
| タイトル | ||||||
| タイトル | Imaging the role of TLR4 on cell proliferation and inflammation after cerebral ischemia by PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moraga, Ana
× Moraga, Ana× Gómez-Vallejo, Vanessa× Isabel, Cuartero María× Szczupak, Boguslaw× San, Sebastián Eneko× Markuerkiaga, Irati× M., Pradillo Jesús× Higuchi, Makoto× Llop, Jordi× Ángeles, Moro María× Martín, Abraham× Lizasoain, Ignacio× 樋口 真人 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The influence of Toll-Like Receptor 4 (TLR4) on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging (MRI) and positron emission tomography (PET) with [18F]FLT and [11C]PK11195 at 2, 7 and 14 days following cerebral ischemia in TLR4+/+ and TLR4-/- mice. MRI showed similar infarction volumes in both groups. Despite this, PET with [18F]FLT and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of TLR4 after cerebral ischemia. | |||||
| 書誌情報 |
Journal of Cerebral Blood Flow and Metabolism 巻 36, 号 4, p. 702-708, 発行日 2016-01 |
|||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15597016 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26787106 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1177/0271678X15627657 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jcb.sagepub.com/content/early/2016/01/18/0271678X15627657.full | |||||
| 関連名称 | http://jcb.sagepub.com/content/early/2016/01/18/0271678X15627657.full | |||||
