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Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan
https://repo.qst.go.jp/records/47550
https://repo.qst.go.jp/records/47550f7eace40-0198-4f8f-95b7-37037965b68c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-26 | |||||
| タイトル | ||||||
| タイトル | Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishida, Yasushi
× Ishida, Yasushi× Qiu, Dongmei× Maeda, Miho× Fujimoto, Junichiro× Kigasawa, Hisato× Kobayashi, Ryoji× Sato, Maho× Okamura, Jun× Yoshinaga, Shinji× Rikiishi, Takeshi× Shichino, Hiroyuki× Kiyotani, Chikako× Kudo, Kazuko× Asami, Keiko× Hori, Hiroki× Kawaguchi, Hiroshi× Inada, Hiroko× Adachi, Souichi× Manabe, Atsushi× Kuroda, Tatsuo× 吉永 信治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background The epidemiology of secondary cancers in childhood cancer survivors has been unknown in Asian countries. Our aim is to assess the incidence and risk factors for secondary cancers through a nationwide survey in Japan. \nMethods A retrospective cohort study comprising 10,069 children who were diagnosed with cancer between 1980 and 2009 was conducted in 15 Japanese hospitals. The cumulative incidence rate was calculated using death as the competing risk and compared by the Gray method. The standardized incidence ratio (SIR) was defined as the ratio of the number of observed cancers divided by the number of expected cancers. The risk factors were analyzed using Cox regression analysis. \nResults One hundred and twenty-eight patients (1.3 %) developed secondary cancers within a median follow-up of 8.4 years. The cumulative incidence rate was 1.1 % (95 % confidence interval [CI] 0.9–1.4) at 10 years and 2.6 % (95 % CI 2.1–3.3) at 20 years after primary cancer diagnosis. Sensitivity analysis, limited to 5-year survivors (n = 5,387), confirmed these low incidence rates. The SIR of secondary cancers was 12.1 (95 % CI 10.1–14.4). In the Cox analysis, the hazard ratios for secondary cancers were 3.81 (95 % CI 1.53–9.47) for retinoblastoma, 2.78 (95 % CI 1.44–5.38) for bone/soft tissue sarcomas, and 1.81 (95 % CI 1.16–2.83) for allogeneic stem cell transplantation. \nConclusions The cumulative incidence of secondary cancers in children in Japan was not high; however, the SIR was relatively high. Retinoblastoma or sarcoma in addition to allogeneic stem cell transplantation were significant risk factors for secondary cancers. |
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| 書誌情報 |
International Journal of Clinical Oncology 巻 21, 号 3, p. 506-516, 発行日 2015-11 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1341-9625 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s10147-015-0927-z | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://link.springer.com/article/10.1007/s10147-015-0927-z | |||||
| 関連名称 | http://link.springer.com/article/10.1007/s10147-015-0927-z | |||||
