ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

Neurosteroidogenesis today: Novel targets for neuroactive steroid synthesis and action and their relevance for translational research.

https://repo.qst.go.jp/records/47545
https://repo.qst.go.jp/records/47545
40e594cb-0b4a-470a-a6c7-ab85425af66c
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-09-06
タイトル
タイトル Neurosteroidogenesis today: Novel targets for neuroactive steroid synthesis and action and their relevance for translational research.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Porcu, Patrizia

× Porcu, Patrizia

WEKO 476475

Porcu, Patrizia

Search repository
Barron, Anna

× Barron, Anna

WEKO 476476

Barron, Anna

Search repository
Anne, Frye Cheryl

× Anne, Frye Cheryl

WEKO 476477

Anne, Frye Cheryl

Search repository
A, Walf Alicia

× A, Walf Alicia

WEKO 476478

A, Walf Alicia

Search repository
Yang, Song-Yu

× Yang, Song-Yu

WEKO 476479

Yang, Song-Yu

Search repository
He, Xue-Ying

× He, Xue-Ying

WEKO 476480

He, Xue-Ying

Search repository
Leslie, Morrow A

× Leslie, Morrow A

WEKO 476481

Leslie, Morrow A

Search repository
Carlo, Panzica Gian

× Carlo, Panzica Gian

WEKO 476482

Carlo, Panzica Gian

Search repository
C, Melcangi Roberto

× C, Melcangi Roberto

WEKO 476483

C, Melcangi Roberto

Search repository
Barron Anna

× Barron Anna

WEKO 476484

en Barron Anna

Search repository
抄録
内容記述タイプ Abstract
内容記述 Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly alter neuronal excitability by binding to membrane receptors, in addition to the regulation of gene expression via intracellular steroid receptors. Neuroactive steroids induce potent anxiolytic, antidepressant, anticonvulsant, sedative, analgesic and amnesic effects, mainly through interaction with the γ-amino-butyric type A (GABAA ) receptor. They also exert neuroprotective, neurotrophic and antiapoptotic effects in several animal models of neurodegenerative diseases. Neuroactive steroids regulate many physiological functions such as stress response, puberty, ovarian cycle, pregnancy and reward. Their levels are altered in several neuropsychiatric and neurologic diseases and both preclinical and clinical studies emphasise a therapeutic potential of neuroactive steroids for these diseases, whereby symptomatology ameliorates upon restoration of neuroactive steroid concentrations. However, direct administration of neuroactive steroids has several challenges, including pharmacokinetics, low bioavailability, addiction potential, safety and tolerability that limit its therapeutic use. Therefore, modulation of neurosteroidogenesis to restore the altered endogenous neuroactive steroid tone may represent a better therapeutic approach. This review summarizes recent approaches that target the neuroactive steroid biosynthetic pathway at different levels in order to promote neurosteroidogenesis. These include modulation of neurosteroidogenesis through ligands of the translocator protein 18 kDa (TSPO), and the pregnane xenobiotic receptor (PXR), as well as targeting of specific neurosteroidogenic enzymes like 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) or P450 side chain cleavage (P450scc). Enhanced neurosteroidogenesis through these targets may be beneficial for neurodegenerative diseases such as Alzheimer's disease and age-related dementia, but also for neuropsychiatric diseases, including alcohol use disorders. This article is protected by copyright. All rights reserved.
書誌情報 Journal of neuroendocrinology

巻 28, 号 2, p. 12351, 発行日 2015-12
出版者
出版者 Wiley & Sons
ISSN
収録物識別子タイプ ISSN
収録物識別子 0953-8194
PubMed番号
識別子タイプ PMID
関連識別子 26681259
DOI
識別子タイプ DOI
関連識別子 10.1111/jne.12351
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 23:38:31.074873
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3