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Assessment of renal function by 7T MRI and prototype of contrast agent - Experimental model
https://repo.qst.go.jp/records/47521
https://repo.qst.go.jp/records/4752158117a60-f3b1-4739-8fb1-68ab990d48de
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-30 | |||||
| タイトル | ||||||
| タイトル | Assessment of renal function by 7T MRI and prototype of contrast agent - Experimental model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bakalova, Rumiana
× Bakalova, Rumiana× Hadjidekov, George× Zhelev, Zhivko× Zlateva, Genoveva× Spasov, Lubomir× Aoki, Ichio× バカロバ ルミアナ× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study shows that nitroxide derivative (carbamoyl-PROPXYL) is suitable 1H-MRI contrast probe for visualization of hypercholesterolemia-induced renal dysfunction in intact animals and clarifying the mechanism(s) of renal damage mediated by cholesterol. The probe was applied in a concentration, which was 3 times lower than the LD50 for intravenous administration in C57Bl/6 mice. Since the probe is excreted by kidneys, it could be considered harmless for mammalians in the selected dose and appropriate candidate for translational research. The data were compared with those, obtained by conventional 1H-MRI contrast agent Gd/DTPA for assessment of renal function in experimental animals and patients. | |||||
| 書誌情報 |
Rentgenologiya i Radiologiya 巻 50, 号 3, p. 197-201, 発行日 2011-12 |
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