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Correlation of frontal atrophy with behavioral changes in amyotrophic lateral sclerosis
https://repo.qst.go.jp/records/47512
https://repo.qst.go.jp/records/47512f371eb91-9333-49f0-a54b-a900ce35adb9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-25 | |||||
| タイトル | ||||||
| タイトル | Correlation of frontal atrophy with behavioral changes in amyotrophic lateral sclerosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Terada, Tatsuhiro
× Terada, Tatsuhiro× Obi, Tomokazu× Miyata, Jun× Kubota, Manabu× Yoshizumi, Miho× Murai, Toshiya× Yamazaki, Kinya× Mizoguchi, Kouichi× 久保田 学 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Recent studies have linked cognitive impairment in amyotrophic lateral sclerosis (ALS) to frontotemporal pathology. Aim: We examined possible associations between behavior changes and regional gray matter volume in early ALS and assessed whether the volume changes were independent of physical impairments. Methods: Seventeen ALS patients with Mini-Mental State Examination ≥24, no need for assistance in daily life, normal respiratory tests (respiratory function test and arterial blood gas analytes), and eleven age-matched controls, underwent structural MRI. Behavioral changes were assessed with family-rating Frontal Systems Behavior Scale (FrSBe). We applied voxel-based morphometry to investigate the correlation between FrSBe and gray matter volume and assessed the correlation of volume with ALS Functional Rating Scale (ALSFRS) and respiratory tests. Results: Current FrSBe were significantly higher than retrospective scores assessing the status before onset, most notably in apathy. The volumes of right middle and left medial frontal gyri in ALS were negatively correlated with FrSBe, whereas they were not correlated with ALSFRS and respiratory tests. The volume of right frontal cluster, but not left medial frontal cluster, was significantly smaller than that of controls. Conclusions: Regional atrophy within frontal lobe was associated with behavioral dysfunction in early ALS, this association was independent of physical factors. |
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| 書誌情報 |
Neurology and Clinical Neuroscience 巻 4, 号 3, p. 85-92, 発行日 2016-03 |
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| 出版者 | ||||||
| 出版者 | Wiley Online Library | |||||
