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Association of IQ Changes and Progressive Brain Changes in Patients With Schizophrenia.
https://repo.qst.go.jp/records/47511
https://repo.qst.go.jp/records/4751110760aaf-5661-4071-a069-b80af878628c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-25 | |||||
| タイトル | ||||||
| タイトル | Association of IQ Changes and Progressive Brain Changes in Patients With Schizophrenia. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kubota, Manabu
× Kubota, Manabu× E, M van Haren Neeltje× V, Haijma Sander× G, Schnack Hugo× Cahn, Wiepke× E, Hulshoff Pol Hilleke× S, Kahn René× 久保田 学 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | IMPORTANCE: Although schizophrenia is characterized by impairments in intelligence and the loss of brain volume, the relationship between changes in IQ and brain measures is not clear. OBJECTIVE: To investigate the association between IQ and brain measures in patients with schizophrenia across time. DESIGN, SETTING, AND PARTICIPANTS: Case-control longitudinal study at the Department of Psychiatry at the University Medical Center Utrecht, Utrecht, the Netherlands, comparing patients with schizophrenia and healthy control participants between September 22, 2004, and April 17, 2008. Magnetic resonance imaging of the brain and IQ scores were obtained at baseline and the 3-year follow-up. Participants included 84 patients with schizophrenia (mean illness duration, 4.35 years) and 116 age-matched healthy control participants. MAIN OUTCOMES AND MEASURES: Associations between changes in IQ and the total brain, cerebral gray matter, cerebral white matter, lateral ventricular, third ventricles, cortical, and subcortical volumes; cortical thickness; and cortical surface area. RESULTS: Cerebral gray matter volume (P = .006) and cortical volume (P = .03) and thickness (P = .02) decreased more in patients with schizophrenia across time compared with control participants. Patients showed additional loss in cortical volume and thickness of the right supramarginal, posterior superior temporal, left supramarginal, left postcentral, and occipital regions (P values were between <.001 and .03 after clusterwise correction). Although IQ increased similarly in patients with schizophrenia and control participants, changes in IQ were negatively correlated with changes in lateral ventricular volume (P = .05) and positively correlated with changes in cortical volume (P = .007) and thickness (P = .004) only in patients with schizophrenia. Positive correlations between changes in IQ and cortical volume and thickness were found globally and in widespread regions across frontal, temporal, and parietal cortices (P values were between <.001 and .03 after clusterwise correction). These findings were independent of symptom severity at follow-up, cannabis use, and the use of cumulative antipsychotic medications during the 3 years of follow-up. CONCLUSIONS AND RELEVANCE: Progressive brain tissue loss in schizophrenia is related to relative cognitive decline during the early course of illness. |
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| 書誌情報 |
JAMA psychiatry 巻 72, 号 8, p. 803-812, 発行日 2015-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2168-622X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26083394 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1001/jamapsychiatry.2015.0712 | |||||
