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  1. 原著論文

Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia.

https://repo.qst.go.jp/records/47509
https://repo.qst.go.jp/records/47509
2fb48a4a-25e7-403c-b8ae-51fe56de3722
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-08-25
タイトル
タイトル Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Uwatoko, Teruhisa

× Uwatoko, Teruhisa

WEKO 476051

Uwatoko, Teruhisa

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Yoshizumi, Miho

× Yoshizumi, Miho

WEKO 476052

Yoshizumi, Miho

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Miyata, Jun

× Miyata, Jun

WEKO 476053

Miyata, Jun

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Ubukata, Shiho

× Ubukata, Shiho

WEKO 476054

Ubukata, Shiho

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Fujiwara, Hironobu

× Fujiwara, Hironobu

WEKO 476055

Fujiwara, Hironobu

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Kawada, Ryosaku

× Kawada, Ryosaku

WEKO 476056

Kawada, Ryosaku

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Kubota, Manabu

× Kubota, Manabu

WEKO 476057

Kubota, Manabu

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Sasamoto, Akihiko

× Sasamoto, Akihiko

WEKO 476058

Sasamoto, Akihiko

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Sugihara, Genichi

× Sugihara, Genichi

WEKO 476059

Sugihara, Genichi

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Aso, Toshihiko

× Aso, Toshihiko

WEKO 476060

Aso, Toshihiko

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Urayama, Shinichi

× Urayama, Shinichi

WEKO 476061

Urayama, Shinichi

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Fukuyama, Hidenao

× Fukuyama, Hidenao

WEKO 476062

Fukuyama, Hidenao

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Murai, Toshiya

× Murai, Toshiya

WEKO 476063

Murai, Toshiya

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Takahashi, Hidehiko

× Takahashi, Hidehiko

WEKO 476064

Takahashi, Hidehiko

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久保田 学

× 久保田 学

WEKO 476065

en 久保田 学

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高橋 英彦

× 高橋 英彦

WEKO 476066

en 高橋 英彦

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抄録
内容記述タイプ Abstract
内容記述 Improving quality of life has been recognized as an important outcome for schizophrenia treatment, although the fundamental determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and objective quality of life in schizophrenia patients. Thirty-three schizophrenia patients and 42 age-, sex-, and education-matched healthy participants underwent magnetic resonance imaging. The Quality of Life Scale was used to measure objective quality of life in schizophrenia patients. Voxel-based morphometry was performed to identify regional brain alterations that correlate with Quality of Life Scale score in the patient group. Schizophrenia patients showed gray matter reductions in the frontal, temporal, limbic, and subcortical regions. We then performed voxel-based multiple regression analysis in these regions to identify any correlations between regional gray matter volume and Quality of Life Scale scores. We found that among four subcategories of the scale, the Instrumental Role category score correlated with gray matter volume in the right anterior insula in schizophrenia patients. In addition, this correlation was shown to be mediated by negative symptoms. Our findings suggest that the neural basis of objective quality of life might differ topographically from that of subjective QOL in schizophrenia.
書誌情報 PloS one

巻 10, 号 11, p. e0142018-1-e0142018-12, 発行日 2015-11
ISSN
収録物識別子タイプ ISSN
収録物識別子 1932-6203
PubMed番号
識別子タイプ PMID
関連識別子 26544607
DOI
識別子タイプ DOI
関連識別子 10.1371/journal.pone.0142018
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