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Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia.
https://repo.qst.go.jp/records/47509
https://repo.qst.go.jp/records/475092fb48a4a-25e7-403c-b8ae-51fe56de3722
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-25 | |||||
| タイトル | ||||||
| タイトル | Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Uwatoko, Teruhisa
× Uwatoko, Teruhisa× Yoshizumi, Miho× Miyata, Jun× Ubukata, Shiho× Fujiwara, Hironobu× Kawada, Ryosaku× Kubota, Manabu× Sasamoto, Akihiko× Sugihara, Genichi× Aso, Toshihiko× Urayama, Shinichi× Fukuyama, Hidenao× Murai, Toshiya× Takahashi, Hidehiko× 久保田 学× 高橋 英彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Improving quality of life has been recognized as an important outcome for schizophrenia treatment, although the fundamental determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and objective quality of life in schizophrenia patients. Thirty-three schizophrenia patients and 42 age-, sex-, and education-matched healthy participants underwent magnetic resonance imaging. The Quality of Life Scale was used to measure objective quality of life in schizophrenia patients. Voxel-based morphometry was performed to identify regional brain alterations that correlate with Quality of Life Scale score in the patient group. Schizophrenia patients showed gray matter reductions in the frontal, temporal, limbic, and subcortical regions. We then performed voxel-based multiple regression analysis in these regions to identify any correlations between regional gray matter volume and Quality of Life Scale scores. We found that among four subcategories of the scale, the Instrumental Role category score correlated with gray matter volume in the right anterior insula in schizophrenia patients. In addition, this correlation was shown to be mediated by negative symptoms. Our findings suggest that the neural basis of objective quality of life might differ topographically from that of subjective QOL in schizophrenia. | |||||
| 書誌情報 |
PloS one 巻 10, 号 11, p. e0142018-1-e0142018-12, 発行日 2015-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1932-6203 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26544607 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1371/journal.pone.0142018 | |||||
