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  1. 原著論文

[(11) C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study.

https://repo.qst.go.jp/records/47489
https://repo.qst.go.jp/records/47489
f35b1ae9-04b4-476b-883b-9af33abd801a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-08-22
タイトル
タイトル [(11) C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Takuwa, Hiroyuki

× Takuwa, Hiroyuki

WEKO 475807

Takuwa, Hiroyuki

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Maeda, Jun

× Maeda, Jun

WEKO 475808

Maeda, Jun

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Ikoma, Yoko

× Ikoma, Yoko

WEKO 475809

Ikoma, Yoko

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Tokunaga, Masaki

× Tokunaga, Masaki

WEKO 475810

Tokunaga, Masaki

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Wakizaka, Hidekatsu

× Wakizaka, Hidekatsu

WEKO 475811

Wakizaka, Hidekatsu

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Uchida, Shouko

× Uchida, Shouko

WEKO 475812

Uchida, Shouko

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Kanno, Iwao

× Kanno, Iwao

WEKO 475813

Kanno, Iwao

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Taniguchi, Junko

× Taniguchi, Junko

WEKO 475814

Taniguchi, Junko

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Ito, Hiroshi

× Ito, Hiroshi

WEKO 475815

Ito, Hiroshi

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 475816

Higuchi, Makoto

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田桑 弘之

× 田桑 弘之

WEKO 475817

en 田桑 弘之

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前田 純

× 前田 純

WEKO 475818

en 前田 純

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生駒 洋子

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WEKO 475819

en 生駒 洋子

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徳永 正希

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WEKO 475820

en 徳永 正希

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脇坂 秀克

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WEKO 475821

en 脇坂 秀克

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菅野 巖

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WEKO 475822

en 菅野 巖

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谷口 順子

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WEKO 475823

en 谷口 順子

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伊藤 浩

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WEKO 475824

en 伊藤 浩

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樋口 真人

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WEKO 475825

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抄録
内容記述タイプ Abstract
内容記述 Anesthesia and restraint stress have profound impacts on brain functions, including neural activity and cerebrovascular function, possibly influencing functional and neurochemical positron emission tomography (PET) imaging data. For circumventing this effect, we developed an experimental system enabling PET imaging of free-walking awake mice with minimal restraints by fixing the head to a holder. The applicability of this system was investigated by performing PET imaging of D2 dopamine receptors with [(11) C]raclopride under the following three different conditions: (1) free-walking awake state; (2) 1.5% isoflurane anesthesia; and (3) whole-body restraint without anesthesia. [(11) C]raclopride binding potential (BPND ) values under isoflurane anesthesia and restrained awake state were significantly lower than under free-walking awake state (P < 0.01). Heart rates in restrained awake mice were significantly higher than those in free-walking awake mice (P < 0.01), suggesting that free-walking awake state minimized restraint stress during the PET scan. [(11) C] raclopride-PET with methamphetamine (METH) injection was also performed in awake and anesthetized mice. METH-induced reduction of [(11) C]raclopride BPND in anesthetized mice showed a trend to be less than that in free-walking awake mice, implying that pharmacological modulation of dopaminergic transmissions could be sensitively captured by PET imaging of free-walking awake mice. We concluded that our system is of utility as an in vivo assaying platform for studies of brain functions and neurotransmission elements in small animals, such as those modeling neuropsychiatric disorders. Synapse 69:600-606, 2015. © 2015 Wiley Periodicals, Inc.
書誌情報 Synapse (New York, N.Y.)

巻 69, 号 12, p. 600-606, 発行日 2015-10
出版者
出版者 Wiley
ISSN
収録物識別子タイプ ISSN
収録物識別子 0887-4476
PubMed番号
識別子タイプ PMID
関連識別子 26360510
DOI
識別子タイプ DOI
関連識別子 10.1002/syn.21864
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